Amphinase

Amphinase
Crystallographic structure of amphinase.[1]
Identifiers
Organism Rana pipiens
Symbol n/a
PDB 2P7S
UniProt P85073
Other data
EC number 3.1.27

Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates.[2] Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells.[3]

References

  1. ↑ Singh, U. P.; Ardelt, W.; Saxena, S. K.; Holloway, D. E.; Vidunas, E.; Lee, H. S.; Saxena, A.; Shogen, K.; Acharya, K. R. (2007). "Enzymatic and Structural Characterisation of Amphinase, a Novel Cytotoxic Ribonuclease from Rana pipiens Oocytes". Journal of Molecular Biology 371: 93. doi:10.1016/j.jmb.2007.04.071.
  2. ↑ Singh, U. P.; Ardelt, W.; Saxena, S. K.; Holloway, D. E.; Vidunas, E.; Lee, H. S.; Saxena, A.; Shogen, K.; Acharya, K. R. (2007). "Enzymatic and Structural Characterisation of Amphinase, a Novel Cytotoxic Ribonuclease from Rana pipiens Oocytes". Journal of Molecular Biology 371: 93. doi:10.1016/j.jmb.2007.04.071.
  3. ↑ Ardelt, W; Shogen, K; Darzynkiewicz, Z (2008). "Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes". Current pharmaceutical biotechnology 9 (3): 215–25. PMC 2586917. PMID 18673287.