Amikhelline

Amikhelline

Systematic (IUPAC) name
9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyrano[3,2-f][1]benzoxol-5-one
Clinical data
Pharmacokinetic data
Metabolism	none
Identifiers
CAS Registry Number	4439-67-2 Y
ATC code	None
PubChem	CID 71198
ChemSpider	64334 Y
UNII	BD9T227F6M Y
ChEMBL	CHEMBL2104025
Chemical data
Formula	C18H21NO5
Molecular mass	331.363 g/mol
SMILES O=C/1c3c(O\C(=C\1)C)c(OCCN(CC)CC)c2occc2c3O
InChI InChI=1S/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3  Y Key:QZBPFSZZMYTRIA-UHFFFAOYSA-N  Y
Y (what is this?)  (verify)

Amikhelline is an antimitotic drug.^[1] It acts as a DNA intercalator^[2] and inhibits DNA polymerase.^[3]

References

1. ↑ Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales. 1985;179(3):331-9. PMID 2417673
2. ↑ Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. Biochimie. 1973;55(11):1415-20. PMID 4364376
3. ↑ Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. Biochimie. 1976;58(6):689-95. PMID 60141