Amezinium metilsulfate

Amezinium metilsulfate
Systematic (IUPAC) name

6-Methoxy-1-phenylpyridazin-1-ium-4-amine; methyl sulfate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Registry Number	30578-37-1^N
ATC code	C01CA25
PubChem	CID 71926
ChemSpider	64937^Y
UNII	03NR868ICX^N
KEGG	D01304^Y
ChEMBL	CHEMBL2106667^N
Chemical data
Formula	C₁₂H₁₅N₃O₅S
Molecular mass	313.32 g/mol
SMILES COC1=[N+](N=CC(=C1)N)C2=CC=CC=C2.COS(=O)(=O)[O-]
InChI InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) ^Y Key:ZEASXVYVFFXULL-UHFFFAOYSA-N ^Y
N (what is this?) (verify)

Amezinium metilsulfate (INN, trade name Regulton) is a sympathomimetic drug used for the treatment of low blood pressure. It has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.^[1]^[2]

References

↑ Araújo, D; Caramona, MM; Osswald, W (1983). "On the mechanism of action of amezinium methylsulphate on the dog saphenous vein". European Journal of Pharmacology 90 (2–3): 203–14. doi:10.1016/0014-2999(83)90238-8. PMID 6873182.
↑ Lenke, D.; Gries, J.; Kretzschmar, R. (1981). "Pharmacology of amezinium, a novel antihypotensive drug. III. Studies on the mechanism of action". Arzneimittel-Forschung 31 (9a): 1558–1565. PMID 7197970.

Cardiac stimulants excluding cardiac glycosides (C01C)

Adrenergic and
dopaminergic agents

Adrenergic agonists

α	Metaraminol Phenylephrine Methoxamine Norfenefrine Oxedrine Midodrine Mephentermine

β	Dobutamine Arbutamine Isoprenaline Prenalterol

mixed	Amezinium metilsulfate Epinephrine # Norepinephrine Etilefrine

Dopamine agonists

Fenoldopam

Both

Unknown/ungrouped

Phosphodiesterase inhibitors (PDE3I)

Other cardiac stimulants

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of the heart

Description	Anatomy Physiology Development

Disease	Injury Congenital Neoplasms and cancer Other Symptoms and signs eponymous Blood tests

Treatment	Procedures Drugs glycosides other stimulants antiarrhythmics vasodilators