Ameltolide

Ameltolide
Systematic (IUPAC) name

4-Amino-N-(2,6-dimethylphenyl)benzamide
Clinical data
Identifiers
CAS Registry Number	787-93-9
ATC code	None
PubChem	CID 13086
ChemSpider	12541
Chemical data
Formula	C₁₅H₁₆N₂O
Molecular mass	240.300 g/mol
SMILES O=C(Nc1c(cccc1C)C)c2ccc(N)cc2
InChI InChI=1S/C15H16N2O/c1-10-4-3-5-11(2)14(10)17-15(18)12-6-8-13(16)9-7-12/h3-9H,16H2,1-2H3,(H,17,18) Key:HZIWGOAXOBPQGY-UHFFFAOYSA-N

Ameltolide, a 4-aminobenzamide derivative, is an experimental anticonvulsant agent, effective at inhibiting seizures in animal models.^[1] It is non-toxic at dosing levels and no undesirable side effects are attributable to its application.^[2]

References

↑ Robertson, David W.; Beedle, E. E.; Krushinski, Joseph H.; Lawson, Ronald R.; Parli, C. John; Potts, Brian; Leander, J. David (1991). "Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant". Journal of Medicinal Chemistry 34 (4): 1253–7. doi:10.1021/jm00108a003. PMID 2016702.
↑ Higdon, Gary L.; McKinley, Edmund R.; Markham, Janet K. (1991). "Ameltolide. I: Developmental toxicology studies of a novel anticonvulsant". Teratology 44 (1): 37–44. doi:10.1002/tera.1420440107. PMID 1957261.