Amaninamide
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Names | |
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Other names
4-(2-mercapto-L-tryptophan)-alpha-Amanitin | |
Identifiers | |
58311-65-2 | |
ChemSpider | 2299516 ![]() |
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Jmol-3D images | Image Image |
PubChem | 3035225 |
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Properties | |
C39H54N10O13S | |
Molar mass | 902.97 g/mol |
Appearance | Colorless, crystalline solid |
Soluble | |
Solubility in ethanol, methanol | Soluble |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
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Infobox references | |
Amaninamide is a cyclic nonribosomal peptide. It is one of the amatoxins, all of which are found in several members of the Amanita genus of mushrooms.
Toxicology
Like other amatoxins, amaninamide is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]
See also
References
- ↑ M. Cochet-Meillhac and Chambon P. (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim Biophys Acta 353 (2): 160–184. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
External links
- Amatoxins REVISED
- Poisonous Mushrooms (German)
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