alpha-Hydroxyglutaric acid
Names | |
---|---|
IUPAC name
2-Hydroxypentanedioic acid | |
Other names
2-Hydroxyglutaric acid | |
Identifiers | |
2889-31-8 | |
ChEBI | CHEBI:17084 |
ChemSpider | 42 |
| |
Jmol-3D images | Image Image |
KEGG | C02630 |
MeSH | Alpha-hydroxyglutarate |
PubChem | 43 |
| |
Properties | |
Molecular formula |
C5H8O5 |
Molar mass | 148.11 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
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Infobox references | |
α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.