Aloe emodin

Aloe emodin
Systematic (IUPAC) name
1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
Clinical data
Oral
Identifiers
481-72-1 
None
PubChem CID 10207
ChemSpider 9792 Yes
KEGG C10294 Yes
ChEBI CHEBI:2607 
ChEMBL CHEMBL40275 Yes
Chemical data
Formula C15H10O5
270.24 g/mol
Physical data
Melting point 223 to 224 °C (433 to 435 °F) Sublimes in CO2 stream
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Aloe emodin is an anthraquinone present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action.[1] Aloe emodin is not carcinogenic when applied to the skin, althougth it may increase the carcinogenicity of some kind of radiation.[2][3] Aloe emodin is found in the gel, sap or leaves of Aloe vera the bark of Frangula (Rhamnus frangula) and Cascara Sagrada (Rhamnus purshiana), the leaves of Senna (Cassia angustifolia), and the rhizome of Rhubarb (Rheum rhaponticum). It has a marked anti-viral effect in vitro against both herpes simplex virus (HSV) type 1 and 2.[4]

References

  1. ↑ The Merck Index, 12th Edition. 313
  2. ↑ Badgwell, DB; Walker, CM; Baker, WT; Strickland, FM (2004). "Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors". Molecular carcinogenesis 39 (3): 127–38. doi:10.1002/mc.10170. PMID 14991742.
  3. ↑ National Toxicology, Program (2010). "Photocarcinogenesis study of aloe vera CAS NO. 481-72-1(Aloe-emodin) in SKH-1 mice (simulated solar light and topical application study)". National Toxicology Program technical report series (553): 7–33, 35–97, 99–103 passim. PMID 21031007.
  4. ↑ http://www.google.com/patents/US4670265 Aloe emodin and other anthraquinones and anthraquinone-like compounds from plants virucidal against herpes simplex viruses

See also