Allan Maxam
| Allan Maxam | |
|---|---|
| Born | October 28, 1942 |
| Doctoral advisor | Walter Gilbert |
| Known for | DNA sequencing |
Allan Maxam is one of the pioneers of molecular genetics. He was one of the contributors to develop a DNA sequencing method at Harvard University, while working as a student in the laboratory of Walter Gilbert.[1][2]
Walter Gilbert and Allan Maxam developed a DNA sequencing method which combined chemicals that cut DNA only at specific bases with radioactive labeling and electrophoresis through acrylamde gels to determine the sequence of long DNA segments.[3]
References
- ↑ Maxam, A M; Gilbert, W (1977), "A new method for sequencing DNA.", Proc. Natl. Acad. Sci. U.S.A. (Feb 1977) 74 (2): 560–4, doi:10.1073/pnas.74.2.560, PMC 392330, PMID 265521
- ↑ DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980
- ↑ Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560
- Gilbert, Walter and Maxam. Allan, The Nuclcotide Sequence of the Lac Operator, Proc. Natl. Acad. Sci. USA 70, 3581-3584 (1973).
- Maxam AM, Tizard R, Skryabin KG, Gilbert W, Promotor region for yeast 5S ribosomal RNA, Nature. 1977 June 16;267(5612):643-5
See also
- Walter Gilbert
- Fred Sanger