Allan Bradley

Professor Allan Bradley

Allan Bradley by Policy Exchange
Fields Mouse genomics[1][2][3][4][5]
Institutions University of Cambridge
Baylor College of Medicine
Wellcome Trust Sanger Institute
Howard Hughes Medical Institute
Alma mater Trinity College, Cambridge[6]
Thesis Isolation characterization and developmental potential of murine embryo-derived stem cells (1986)
Doctoral advisor Martin Evans[7]
Doctoral students Caitlin Stewart[5]
Known for Research using Embryonic stem cells[8]
Notable awards PhD (1986)[9]
Searle Scholar (1988)
EMBO member (2006)
Fellow of the Royal Society (2002)
Website
www.sanger.ac.uk/research/faculty/abradley
www.sanger.ac.uk/research/projects/mousegenomics

Professor Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute.[10][11][12][13]

Education

Bradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD[9] degrees in Genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans.[6][7]

Career

Following his PhD, Bradley was appointed Assistant Professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988.[14] He won a 1994 DeBakey Awards.[15] Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (after John Sulston) to April 2010, succeeded by Michael Stratton.

Awards

Bradley was elected a Fellow of the Royal Society in 2002. His nomination reads

"Allan Bradley has made important contributions to the technique of mutation of endogenous genes in mice, an approach that has opened up a new era of research in biology. It is impossible to open an issue of a major journal nowadays without coming across an article that describes the consequences of mutating an endogenous gene in mice. The generation of these mice is based on concepts and techniques that can be traced back to experiments performed and published by Bradley fifteen years ago. In the years since, he has not only used ES cell technology to provide key information on the functions of many genes including several important tumour suppressor genes, but has also continued to improve and develop the techniques, technology, and tools for genetic manipulation in the mouse. Today, mice can be generated with changes as subtle as an alteration in a single nucleotide or as extensive as the deletion of millions of base pairs. These alterations will gain increasing importance in genetic experiments aimed at understanding the function of genes in the mammalian genome in the post genome era."[8]

References

  1. ↑ Donehower, L. A.; Harvey, M.; Slagle, B. L.; McArthur, M. J.; Montgomery Jr, C. A.; Butel, J. S.; Bradley, A. (1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours". Nature 356 (6366): 215–221. doi:10.1038/356215a0. PMID 1552940.
  2. ↑ Dalton, D.; Pitts-Meek, S.; Keshav, S.; Figari, I.; Bradley, A.; Stewart, T. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes". Science 259 (5102): 1739–1742. doi:10.1126/science.8456300. PMID 8456300.
  3. ↑ Guo, G.; Wang, W.; Bradley, A. (2004). "Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells". Nature 429 (6994): 891–895. doi:10.1038/nature02653. PMID 15215866.
  4. ↑ Kile, B. T.; Hentges, K. E.; Clark, A. T.; Nakamura, H.; Salinger, A. P.; Liu, B.; Box, N.; Stockton, D. W.; Johnson, R. L.; Behringer, R. R.; Bradley, A.; Justice, M. J. (2003). "Functional genetic analysis of mouse chromosome 11". Nature 425 (6953): 81–86. doi:10.1038/nature01865. PMID 12955145.
  5. ↑ 5.0 5.1 http://www.sanger.ac.uk/research/projects/mousegenomics
  6. ↑ 6.0 6.1 "BRADLEY, Prof. Allan". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
  7. ↑ 7.0 7.1 "Allan Bradley - Wellcome Trust Sanger Institute". Sanger.ac.uk. Archived from the original on 2013-11-13.
  8. ↑ 8.0 8.1 "Library and Archive Catalogue". London: The Royal Society. Retrieved 2013-11-14.
  9. ↑ 9.0 9.1 Bradley, Allan (1986). Isolation characterization and developmental potential of murine embryo-derived stem cells (PhD thesis). University of Cambridge.
  10. ↑ "Professor Allan Bradley: a decade at Sanger | Wellcome Trust". Wellcome.ac.uk. 2010-06-15. Retrieved 2012-04-04.
  11. ↑ "Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society - Wellcome Trust Sanger Institute". Sanger.ac.uk. Retrieved 2012-04-04.
  12. ↑ Allan Bradley's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  13. ↑ Kate Kelland (October 12, 2011). "New stem cell method could end need for liver transplants". The National Post.
  14. ↑ "Searle Scholars Program : Allan Bradley (1988)". Searlescholars.net. Retrieved 2012-04-04.
  15. ↑ "Bradley - DeBakey Excellence in Research Awards- Baylor College of Medicine, Houston, Texas". Bcm.edu. Retrieved 2012-04-04.
Non-profit organization positions
Preceded by
John Sulston		 Director of the Wellcome Trust Sanger Institute
2000–2010 		Succeeded by
Michael Stratton