Alisertib
Names | |
---|---|
IUPAC name
4-{[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid | |
Systematic IUPAC name
4-{[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid | |
Identifiers | |
1028486-01-2 | |
ChEMBL | ChEMBL483158 |
ChemSpider | 24700147 |
| |
Jmol-3D images | Image |
KEGG | D10085 |
PubChem | 24771867 |
| |
UNII | T66ES73M18 |
Properties | |
Molecular formula |
C27H20ClFN4O4 |
Molar mass | 518.92 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
Infobox references | |
Alisertib (MLN8237) is an orally available selective aurora A kinase inhibitor developed by Takeda.[1] It is currently being investigated as a treatment for relapsed or refractory peripheral T-cell lymphoma.[2][3]
References
- ↑ Friedberg, JW; Mahadevan, D; Cebula, E; Persky, D; Lossos, I; Agarwal, AB; Jung, J; Burack, R; Zhou, X; Leonard, EJ; Fingert, H; Danaee, H; Bernstein, SH (Jan 1, 2014). "Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas.". Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32 (1): 44–50. doi:10.1200/JCO.2012.46.8793. PMID 24043741.
- ↑ "Millennium Initiates Pivotal Phase 3 Trial of MLN8237 in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma". Takeda Pharmaceutical Company Limited; Millennium Pharmaceuticals, Inc. March 6, 2012. Retrieved 20 March 2014.
- ↑ "Research and Development Pipeline (As of February 5, 2014)" (PDF). Takeda Pharmaceutical Company Limited. February 5, 2014. p. 2. Retrieved 20 March 2014.