Ajmaline

Ajmaline

Systematic (IUPAC) name
(17R,21β)-ajmalan- 17,21-diol OR (1R,9R,10S,13R,14R,16S,18S)- 13-ethyl- 8-methyl- 8,15-diazahexacyclo [14.2.1.01,9.02,7.010,15.012,17] nonadeca- 2(7),3,5-triene- 14,18-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	4360-12-7 Y
ATC code	C01BA05
PubChem	CID 20367
DrugBank	DB01426 Y
ChemSpider	10469368 Y
UNII	1PON08459R Y
KEGG	D00199 N
ChEMBL	CHEMBL1230919 N
Chemical data
Formula	C20H26N2O2
Molecular mass	326.433 g/mol
SMILES CC[C@H]1[C@H]5C[C@@H]4N([C@@H]1O)[C@H]6C[C@]3(c2ccccc2N(C)[C@H]34)[C@H](O)C56
InChI InChI=1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11+,14-,15-,16?,17-,18+,19+,20+/m0/s1  Y Key:CJDRUOGAGYHKKD-SXKXKDIKSA-N  Y
N (what is this?)  (verify)

Ajmaline is an alkaloid that is class Ia antiarrhythmic agent. It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome.

The compound was first isolated by Salimuzzaman Siddiqui in 1931 ^[1] from the roots of Rauwolfia serpentina. He named it ajmaline, after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia.^[2]

See also

• Ajmalicine

References