Adozelesin
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Identifiers | |
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110314-48-2 | |
ChEMBL | ChEMBL35493 |
ChemSpider | 317091 |
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Jmol-3D images | Image |
PubChem | 357194 |
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Properties | |
Molecular formula |
C30H22N4O4 |
Molar mass | 502.52 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
Infobox references | |
Adozelesin is an experimental antitumor drug of the duocarmycin class.[1] It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth.[2]
References
- ↑ Wang, Y; Beerman, TA; Kowalski, D (2001). "Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants". Cancer Research 61 (9): 3787–94. PMID 11325853.
- ↑ Liu, J.-S.; Kuo, S.-R.; McHugh, M. M.; Beerman, T. A.; Melendy, T. (14 January 2000). "Adozelesin Triggers DNA Damage Response Pathways and Arrests SV40 DNA Replication through Replication Protein A Inactivation". Journal of Biological Chemistry 275 (2): 1391–1397. doi:10.1074/jbc.275.2.1391.