Adipose triglyceride lipase

Patatin-like phospholipase domain containing 2

Identifiers

PNPLA2 ; 1110001C14Rik; ATGL; PEDF-R; TTS-2.2; TTS2; iPLA2zeta

External IDs

OMIM: 609059 MGI: 1914103 HomoloGene: 10687 GeneCards: PNPLA2 Gene

3.1.1.3

Gene ontology
Molecular function	• triglyceride lipase activity
Cellular component	• endoplasmic reticulum membrane • lipid particle • cytosol • plasma membrane • integral component of membrane • intracellular membrane-bounded organelle
Biological process	• phospholipid metabolic process • negative regulation of sequestering of triglyceride • positive regulation of triglyceride catabolic process • triglyceride catabolic process • acylglycerol acyl-chain remodeling • small molecule metabolic process • glycerophospholipid biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
0.82 – 0.83 Mb

Chr 7:
141.46 – 141.46 Mb

PubMed search

Adipose triglyceride lipase also known as patatin-like phospholipase domain-containing protein 2 is an enzyme that in humans is encoded by the PNPLA2 gene.^[1]^[2]^[3]^[4]

References

↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
↑ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.
↑ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.
↑ "Entrez Gene: PNPLA2 patatin-like phospholipase domain containing 2".

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Fischer J, Lefèvre C, Morava E et al. (2007). "The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy.". Nat. Genet. 39 (1): 28–30. doi:10.1038/ng1951. PMID 17187067.
Rydén M, Jocken J, van Harmelen V et al. (2007). "Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.". Am. J. Physiol. Endocrinol. Metab. 292 (6): E1847–55. doi:10.1152/ajpendo.00040.2007. PMID 17327373.
Jocken JW, Langin D, Smit E et al. (2007). "Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state.". J. Clin. Endocrinol. Metab. 92 (6): 2292–9. doi:10.1210/jc.2006-1318. PMID 17356053.
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Adipose triglyceride lipase

References

Further reading