Adenosyl-fluoride synthase
| Adenosyl-fluoride synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.63 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, an adenosyl-fluoride synthase (EC 2.5.1.63) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + fluoride
5'-deoxy-5'-fluoroadenosine + L-methionine
Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and fluoride, whereas its two products are 5'deoxy-5'-fluoroadenosine and L-methionine.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:fluoride adenosyltransferase. This enzyme is also called fluorinase.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RQP, 1RQR, 2C2W, 2C4T, 2C4U, 2C5B, 2C5H, 2CBX, and 2CC2.
See also
- Carbon–fluorine bond
- Organofluorine
References
- O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD (2002). "Biochemistry: biosynthesis of an organofluorine molecule". Nature. 416 (6878): 279. doi:10.1038/416279a. PMID 11907567.
- Naismith JH; Huang, F; Deng, H; Schaffrath, C; Spencer, JB; O'Hagan, D; Naismith, JH (2004). "Crystal structure and mechanism of a bacterial fluorinating enzyme". Nature. 427 (6974): 561–5. doi:10.1038/nature02280. PMID 14765200.