Activella

Activella
Combination of
Estradiol	Estrogen
Norethindrone	Progestogen
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a601041
Pregnancy category	US: X (Contraindicated)
Legal status	US: ℞-only
Identifiers
CAS Registry Number	77728-33-7^N
ATC code	G03FA01
N (what is this?) (verify)

Activella (also sold as Estracomb, Kliofem and Novofem) is a combination drug of estradiol and norethindrone acetate used for the treatment of vasomotor symptoms, vulvar and vaginal atrophy and osteoporosis^[1] associated with menopause.

Activella supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethindrone acetate. Activella is marketed by Novo Nordisk.

References

↑ Morabito, Nunziata; Crisafulli, Alessandra; Vergara, Caterina; Gaudio, Agostino; Lasco, Antonino; Frisina, Nicola; D'Anna, Rosario; Corrado, Francesco; Pizzoleo, Maria Antonia; Cincotta, Maria; Altavilla, Domenica; Ientile, Riccardo; Squadrito, Francesco (1 October 2002). "Effects of Genistein and Hormone-Replacement Therapy on Bone Loss in Early Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Study". Journal of Bone and Mineral Research 17 (10): 1904–1912. doi:10.1359/jbmr.2002.17.10.1904.

Progestogens and antiprogestogens

Agonists

1st	Norpregnene Norethisterone^#/Norethisterone acetate/Norethisterone enanthate Etynodiol diacetate Pregnene Ethisterone Norpregnane Norgestrienone

2nd	Norpregnene Levonorgestrel^#/Norgestrel/Norelgestromin

3rd	19-Nortestosterone Desogestrel/Etonogestrel Gestodene Norgestimate

4th	Androstene Drospirenone 19-Norprogesterone Demegestone Nestorone Nomegestrol acetate Promegestone Trimegestone 19-Nortestosterone Dienogest

17-OH	17-Hydroxyprogesterone acetate 17-Hydroxyprogesterone caproate Chlormadinone acetate Cyproterone acetate Medroxyprogesterone Medroxyprogesterone acetate^# Megestrol acetate

Other/ ungrouped	Pregnadiene Medrogestone Pregnenedione Gestonorone Dydrogesterone Haloprogesterone Lynestrenol Norethynodrel Progesterone Proligestone Quingestanol acetate Tibolone Trengestone

Antagonists /
SPRMs

Antagonists
- Aglepristone
- Mifepristone

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of reproductive medicine

Description	Anatomy male female Physiology menstrual cycle Development sex determination and differentiation

Disease	Infections STD and STI Congenital male female Neoplasms and cancer male female gonadal germ cell Other male female Symptoms and signs eponymous

Treatment	Procedures male female Drugs benign prostatic hypertrophy erectile dysfunction and premature ejaculation sexual dysfunction infection STDs hormones androgens estrogens progestogens GnRH prolactin Assisted reproduction Birth control hormonal