Acidic leucine-rich nuclear phosphoprotein 32 family member A

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Rendering based on PDB 2JE0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsANP32A ; C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32
External IDsOMIM: 600832 MGI: 108447 HomoloGene: 133783 GeneCards: ANP32A Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez812511737
EnsemblENSG00000140350ENSMUSG00000032249
UniProtP39687O35381
RefSeq (mRNA)NM_006305NM_009672
RefSeq (protein)NP_006296NP_033802
Location (UCSC)Chr 15:
69.07 – 69.11 Mb		Chr 9:
62.34 – 62.38 Mb
PubMed search

Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene.[1][2][3] It is one of the targets of an oncomiR, MIRN21.

Interactions

Acidic leucine-rich nuclear phosphoprotein 32 family member A has been shown to interact with MAP1B,[4] TAF1A[5] and Protein SET.[5][6]

See also

References

  1. ↑ Chen TH, Brody JR, Romantsev FE, Yu JG, Kayler AE, Voneiff E, Kuhajda FP, Pasternack GR (March 1997). "Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci". Mol Biol Cell 7 (12): 2045–56. doi:10.1091/mbc.7.12.2045. PMC 276049. PMID 8970164.
  2. ↑ Ulitzur N, Humbert M, Pfeffer SR (June 1997). "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules". Proc Natl Acad Sci U S A 94 (10): 5084–9. doi:10.1073/pnas.94.10.5084. PMC 24635. PMID 9144194.
  3. ↑ "Entrez Gene: ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A".
  4. ↑ Opal, Puneet; Garcia Jesus J; Propst Friedrich; Matilla Antoni; Orr Harry T; Zoghbi Huda Y (September 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. (United States) 278 (36): 34691–9. doi:10.1074/jbc.M302785200. ISSN 0021-9258. PMID 12807913.
  5. ↑ 5.0 5.1 Seo, S B; McNamara P; Heo S; Turner A; Lane W S; Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell (United States) 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. ISSN 0092-8674. PMID 11163245.
  6. ↑ Fan, Zusen; Beresford Paul J; Zhang Dong; Lieberman Judy (April 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Mol. Cell. Biol. (United States) 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN 0270-7306. PMC 133744. PMID 11909973.

Further reading

  • Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats.". Cerebellum 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553.
  • Schraven B, Kirchgessner H, Gaber B et al. (1991). "A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate.". Eur. J. Immunol. 21 (10): 2469–77. doi:10.1002/eji.1830211025. PMID 1655467.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Vaesen M, Barnikol-Watanabe S, Götz H et al. (1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biol. Chem. Hoppe-Seyler 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID 8192856.
  • Fink TM, Vaesen M, Kratzin HD et al. (1996). "Localization of the gene encoding the putative human HLA class II associated protein (PHAPI) to chromosome 15q22.3-q23 by fluorescence in situ hybridization". Genomics 29 (1): 309–10. doi:10.1006/geno.1995.1257. PMID 8530098.
  • Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Li M, Makkinje A, Damuni Z (1996). "Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A". Biochemistry 35 (22): 6998–7002. doi:10.1021/bi960581y. PMID 8679524.
  • Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Matilla A, Koshy BT, Cummings CJ et al. (1997). "The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1". Nature 389 (6654): 974–8. doi:10.1038/40159. PMID 9353121.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kadkol SS, Brody JR, Pevsner J et al. (1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer". Nat. Med. 5 (3): 275–9. doi:10.1038/6488. PMID 10086381.
  • Brody JR, Kadkol SS, Mahmoud MA et al. (1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32". J. Biol. Chem. 274 (29): 20053–5. doi:10.1074/jbc.274.29.20053. PMID 10400610.
  • Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
  • Seo SB, McNamara P, Heo S et al. (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
  • Bai J, Brody JR, Kadkol SS, Pasternack GR (2001). "Tumor suppression and potentiation by manipulation of pp32 expression". Oncogene 20 (17): 2153–60. doi:10.1038/sj.onc.1204294. PMID 11360199.
  • Beresford PJ, Zhang D, Oh DY et al. (2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". J. Biol. Chem. 276 (46): 43285–93. doi:10.1074/jbc.M108137200. PMID 11555662.
  • Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science 294 (5548): 1895–901. doi:10.1126/science.1064693. PMID 11729309.