Aceperone

Aceperone
Systematic (IUPAC) name

N-({1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl}methyl)acetamide
Clinical data
Identifiers
CAS Registry Number	807-31-8
ATC code	None
PubChem	CID 13122
ChemSpider	12570
UNII	S69KXZ59AB
ChEMBL	CHEMBL136298
Synonyms	Acetabuton; R 3248
Chemical data
Formula	C₂₄H₂₉F N₂O₂
Molecular mass	396.498 g/mol
SMILES Fc1ccc(cc1)C(=O)CCCN3CCC(c2ccccc2)(CC3)CNC(=O)C
InChI InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28) Key:VDGZERMDPAAZEJ-UHFFFAOYSA-N
Physical data
Melting point	97 to 100 °C (207 to 212 °F) ^[1]

Aceperone is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen Pharmaceutica in the 1960s.^[1]

Because of its learning impairment effects in animals, aceperone has been used as a tool in the study of the biochemical basis of learning.^[2]^[3]^[4]

References

↑ 1.0 1.1 Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines. Janssen, Paul A. J. (1961) BE 606849
↑ Ridley, R. M.; Haystead, T. A. J.; Baker, H. F.; Crow, T. J. (1981). "A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after α-noradrenergic receptor blockade". Pharmacology, Biochemistry and Behavior 14 (6): 849–855. doi:10.1016/0091-3057(81)90373-7.
↑ Baker, H.F.; Ridley, R.M.; Haystead, T.A.J.; Crow, T.J. (1983). "Further consideration of the learning impairment after aceperone in the marmoset: Effects of the drug on shape and colour discrimination and on an alternation task". Pharmacology Biochemistry and Behavior 18 (5): 701. doi:10.1016/0091-3057(83)90009-6.
↑ Scraggs, P. R.; Ridley, R. M. (1979). "The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset". Psychopharmacology 62 (1): 41–5. doi:10.1007/BF00426033. PMID 155838.