Acefurtiamine

Acefurtiamine
Systematic (IUPAC) name

(3E)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-[(furan-2-ylcarbonyl)sulfanyl]pent-3-en-1-yl (acetyloxy)acetate
Clinical data
Identifiers
CAS Registry Number	10072-48-7^N
ATC code	None
PubChem	CID 3037171
ChemSpider	2300987^Y
UNII	6APJ3D1308^Y
ChEMBL	CHEMBL2104090^N
Chemical data
Formula	C₂₁H₂₄N₄O₇S
Molecular mass	476.503 g/mol
SMILES O=C(OCC(=O)OCCC(\SC(=O)c1occc1)=C(/N(C=O)Cc2cnc(nc2N)C)C)C
InChI InChI=1S/C21H24N4O7S/c1-13(25(12-26)10-16-9-23-14(2)24-20(16)22)18(33-21(29)17-5-4-7-30-17)6-8-31-19(28)11-32-15(3)27/h4-5,7,9,12H,6,8,10-11H2,1-3H3,(H2,22,23,24)/b18-13+ ^Y Key:MYBUGVXNAHWTOL-QGOAFFKASA-N ^Y
N (what is this?) (verify)

Acefurtiamine (INN) is an analogue of vitamin B₁ (in a manner similair to the GABAergic activity of the thiamine derivative clomethiazole^[1] which functions as an analgesic agent at sufficient doses {Dosage Range Unlisted}.

See also

Vitamin B₁ analogue

References

↑ William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences (1993). The Extra Pharmacopoeia. Pharmaceutical Press. p. 1053. ISBN 978-0-85369-300-0.

A	α-Carotene β-Carotene Retinol^# Tretinoin

D	D₂ Ergosterol Ergocalciferol^# D₃ 7-Dehydrocholesterol Previtamin D₃ Cholecalciferol 25-hydroxycholecalciferol Calcitriol (1,25-dihydroxycholecalciferol) Calcitroic acid D₄ Dihydroergocalciferol D₅ D analogues Alfacalcidol Dihydrotachysterol Calcipotriol Tacalcitol Paricalcitol

E	Tocopherol Alpha Beta Gamma Delta Tocotrienol Alpha Beta Gamma Delta Tocofersolan

K	Naphthoquinone Phylloquinone (K₁) Menaquinones (K₂) Menadione (K₃)‡ Menadiol (K₄)

B	B₁ Thiamine^# B₁ analogues Acefurtiamine Allithiamine Benfotiamine Fursultiamine Octotiamine Prosultiamine Sulbutiamine B₂ Riboflavin^# B₃ Niacin Nicotinamide^# B₅ Pantothenic acid Dexpanthenol Pantethine B₆ Pyridoxine^#, Pyridoxal phosphate Pyridoxamine Pyritinol B₇ Biotin B₉ Folic acid Dihydrofolic acid Folinic acid Levomefolic acid B₁₂ Cyanocobalamin Hydroxocobalamin Methylcobalamin Cobamamide Choline

C	Ascorbic acid^# Dehydroascorbic acid

Combinations

Multivitamins

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of nutrition

Description	Vitamins metabolism Cofactors Metal metabolism Fats metabolism intermediates lipoproteins Sugars Glycolysis enzymes Glycogenesis and glycogenolysis intermediates Fructose and galactose intermediates

Disease	Vitamins Carbohydrate Lipid storage Metals Other Symptoms and signs eponymous

Treatment	Drugs obesity lipid-modifying Vitamins Mineral supplements