ATP6V0D2

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2

Identifiers

ATP6V0D2 ; ATP6D2; VMA6

External IDs

HomoloGene: 72090 IUPHAR: 830 GeneCards: ATP6V0D2 Gene

3.6.3.14

Gene ontology
Molecular function	• protein binding • hydrogen ion transmembrane transporter activity
Cellular component	• early endosome • endosome membrane • membrane • apical plasma membrane • vacuolar proton-transporting V-type ATPase complex • phagocytic vesicle membrane • proton-transporting V-type ATPase, V0 domain • extracellular vesicular exosome
Biological process	• cellular iron ion homeostasis • insulin receptor signaling pathway • ATP hydrolysis coupled proton transport • transferrin transport • interaction with host • transmembrane transport • phagosome maturation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
85.99 – 86.15 Mb

Chr 4:
19.88 – 19.92 Mb

PubMed search

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. ^[1] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. ^[2]

References

↑ "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2". Retrieved 2012-11-12.
↑ H, Wu; G, Xu; YP, Li (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research 24 (5): 871 - 885. doi:10.1359/jbmr.081239. PMID 19113919. Retrieved 29 January 2015.

ATP6V0D2

References

Further reading