ATG7

Autophagy related 7
Identifiers
Symbols	ATG7 ; APG7-LIKE; APG7L; GSA7
External IDs	OMIM: 608760 MGI: 1921494 HomoloGene: 4662 GeneCards: ATG7 Gene
Gene ontology Molecular function • ubiquitin activating enzyme activity • protein binding • transcription factor binding • Atg12 activating enzyme activity • Atg8 activating enzyme • protein homodimerization activity Cellular component • pre-autophagosomal structure • cytoplasm • cytosol • axoneme Biological process • mitochondrion degradation • liver development • cellular protein modification process • protein lipidation • C-terminal protein lipidation • cellular amino acid metabolic process • cellular response to nitrogen starvation • organelle organization • adult walking behavior • cellular response to starvation • post-embryonic development • positive regulation of autophagy • protein transport • positive regulation of macroautophagy • protein ubiquitination • cerebellar Purkinje cell layer development • pyramidal neuron development • central nervous system neuron axonogenesis • cerebral cortex development • protein catabolic process • regulation of protein ubiquitination • positive regulation of protein modification process • protein modification by small protein conjugation • piecemeal microautophagy of nucleus • positive regulation of apoptotic process • negative regulation of apoptotic process • late nucleophagy • positive regulation of protein catabolic process • neurological system process • cardiac muscle cell development • membrane fusion • cellular response to hyperoxia Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10533	74244
Ensembl	ENSG00000197548	ENSMUSG00000030314
UniProt	O95352	Q9D906
RefSeq (mRNA)	NM_001136031	NM_001253717
RefSeq (protein)	NP_001129503	NP_001240646
Location (UCSC)	Chr 3: 11.27 – 11.56 Mb	Chr 6: 114.64 – 114.86 Mb
PubMed search

Autophagy-related protein 7 is a protein that in humans is encoded by the ATG7 gene.^[1][2]

This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vaculuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.^[2]

References

Further reading