ATF7IP

Activating transcription factor 7 interacting protein

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2RPQ

Identifiers

ATF7IP ; AM; ATF-IP; MCAF; MCAF1; p621

External IDs

OMIM: 613644 MGI: 1858965 HomoloGene: 10051 GeneCards: ATF7IP Gene

Gene ontology
Molecular function	• transcription corepressor activity • protein binding • ATPase activity
Cellular component	• nucleus • transcription factor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • ATP catabolic process • DNA methylation • transcription, DNA-templated • viral process • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of RNA polymerase II transcriptional preinitiation complex assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000171681

ENSMUSG00000030213

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
14.52 – 14.65 Mb

Chr 6:
136.52 – 136.61 Mb

PubMed search

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.^[1]^[2]^[3]

Interactions

ATF7IP has been shown to interact with MBD1.^[4]

References

↑ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
↑ De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215.
↑ "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
↑ Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. (United States) 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.

Further reading

Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yamada K, Kawata H, Shou Z et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
Fujita N, Watanabe S, Ichimura T et al. (2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. PMC 152570. PMID 12665582.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
Wang H, An W, Cao R et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell 12 (2): 475–87. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ichimura T, Watanabe S, Sakamoto Y et al. (2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". J. Biol. Chem. 280 (14): 13928–35. doi:10.1074/jbc.M413654200. PMID 15691849.
Chang LK, Chung JY, Hong YR et al. (2005). "Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1". Nucleic Acids Res. 33 (20): 6528–39. doi:10.1093/nar/gki956. PMC 1298921. PMID 16314315.
Uchimura Y, Ichimura T, Uwada J et al. (2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". J. Biol. Chem. 281 (32): 23180–90. doi:10.1074/jbc.M602280200. PMID 16757475.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.