ASCL2

Achaete-scute family bHLH transcription factor 2

Identifiers

ASCL2 ; ASH2; HASH2; MASH2; bHLHa45

External IDs

OMIM: 601886 MGI: 96920 HomoloGene: 3789 GeneCards: ASCL2 Gene

Gene ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding • protein dimerization activity • E-box binding
Cellular component	• nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • response to hypoxia • placenta development • transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of Schwann cell proliferation • somatic stem cell maintenance • spongiotrophoblast differentiation • spongiotrophoblast layer development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
2.29 – 2.29 Mb

Chr 7:
142.97 – 142.97 Mb

PubMed search

Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.^[1]

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.^[1]

Interactions

ASCL2 has been shown to interact with NCOA6^[2] and RBBP5.^[2]

References

↑ 1.0 1.1 "Entrez Gene: ASCL2 achaete-scute complex homolog 2 (Drosophila)".
↑ 2.0 2.1 Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. ISSN 0270-7306. PMC 140670. PMID 12482968.

Miyamoto T, Jinno Y, Sasaki T et al. (1996). "Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2)". Cytogenet. Cell Genet. 73 (4): 312–4. doi:10.1159/000134364. PMID 8751384.
Alders M, Hodges M, Hadjantonakis AK et al. (1997). "The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts". Hum. Mol. Genet. 6 (6): 859–67. doi:10.1093/hmg/6.6.859. PMID 9175731.
Miyamoto T, Jinno Y, Miura K et al. (1998). "A SacII polymorphism in the human ASCL2 (HASH2) gene region". J. Hum. Genet. 43 (1): 69–70. doi:10.1007/s100380050041. PMID 9610003.
Onions J, Hermann S, Grundström T (2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry 39 (15): 4366–74. doi:10.1021/bi992533u. PMID 10757985.
Westerman BA, Poutsma A, Looijenga LH et al. (2001). "The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization". Placenta 22 (6): 511–8. doi:10.1053/plac.2001.0695. PMID 11440538.
Miyamoto T, Hasuike S, Jinno Y et al. (2002). "The human ASCL2 gene escaping genomic imprinting and its expression pattern". J. Assist. Reprod. Genet. 19 (5): 240–4. doi:10.1023/A:1015362903486. PMC 3468234. PMID 12099555.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Goo YH, Sohn YC, Kim DH et al. (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968.
Jiang B, Mendelson CR (2003). "USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia". Mol. Cell. Biol. 23 (17): 6117–28. doi:10.1128/MCB.23.17.6117-6128.2003. PMC 180905. PMID 12917334.
Koide S, Yoshida I, Tsuji A, Matsuda Y (2004). "The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2". J. Biochem. 134 (3): 433–40. doi:10.1093/jb/mvg161. PMID 14561729.
Jubb AM, Chalasani S, Frantz GD et al. (2006). "Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia". Oncogene 25 (24): 3445–57. doi:10.1038/sj.onc.1209382. PMID 16568095.
Shahib MN, Martaadisoebrata D, Kato H (2007). "Detection of HASH2 (ASCL2) gene expression in gestational trophoblastic disease". The Journal of reproductive medicine 51 (11): 892–6. PMID 17165436.

ASCL2

Interactions

References

Further reading