ASCC3

Activating signal cointegrator 1 complex subunit 3

Identifiers

ASCC3 ; ASC1p200; HELIC1; RNAH

External IDs

OMIM: 614217 MGI: 1925237 HomoloGene: 4973 GeneCards: ASCC3 Gene

Gene ontology
Molecular function	• protein binding • ATP binding • ATP-dependent 3'-5' DNA helicase activity • poly(A) RNA binding
Cellular component	• intracellular • nucleus • cytoplasm • Golgi apparatus • membrane
Biological process	• DNA dealkylation involved in DNA repair • transcription, DNA-templated • regulation of transcription, DNA-templated • cell proliferation • DNA duplex unwinding
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000112249

ENSMUSG00000038774

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
100.96 – 101.33 Mb

Chr 10:
50.59 – 50.85 Mb

PubMed search

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.^[1]^[2]

Interactions

ASCC3 has been shown to interact with RELA,^[3] C-jun^[3] and Serum response factor.^[3]

References

↑ Coulie PG, Ikeda H, Baurain JF, Chiari R (Jun 1999). "Antitumor immunity at work in a melanoma patient". Adv Cancer Res. Advances in Cancer Research 76: 213–42. doi:10.1016/S0065-230X(08)60778-2. ISBN 978-0-12-006676-6. PMID 10218103.
↑ "Entrez Gene: ASCC3 activating signal cointegrator 1 complex subunit 3".
↑ 3.0 3.1 3.2 Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul 2002). "Novel Transcription Coactivator Complex Containing Activating Signal Cointegrator 1". Mol. Cell. Biol. (United States) 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. ISSN 0270-7306. PMC 139772. PMID 12077347.

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Jung DJ, Sung HS, Goo YW et al. (2002). "Novel Transcription Coactivator Complex Containing Activating Signal Cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.