ASB3
| Ankyrin repeat and SOCS box containing 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | ASB3 ; ASB-3 | ||||||||||
| External IDs | OMIM: 605760 MGI: 1929749 HomoloGene: 9391 GeneCards: ASB3 Gene | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 51130 | 65257 | |||||||||
| Ensembl | ENSG00000115239 | ENSMUSG00000020305 | |||||||||
| UniProt | Q9Y575 | Q9WV72 | |||||||||
| RefSeq (mRNA) | NM_001201965 | NM_023906 | |||||||||
| RefSeq (protein) | NP_001188894 | NP_076395 | |||||||||
| Location (UCSC) | Chr 2: 53.76 – 54.09 Mb | Chr 11: 30.95 – 31.1 Mb | |||||||||
| PubMed search | |||||||||||
Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.[1][2]
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.[2]
References
- ↑ Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (May 2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II". Mol Cell Biol 25 (11): 4716–26. doi:10.1128/MCB.25.11.4716-4726.2005. PMC 1140645. PMID 15899873.
- ↑ 2.0 2.1 "Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3".
Further reading
- Kile BT, Schulman BA, Alexander WS et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Kile BT, Viney EM, Willson TA et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.". Gene 258 (1-2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
- Kile BT, Metcalf D, Mifsud S et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice.". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.