ASB1
| Ankyrin repeat and SOCS box containing 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ASB1 ; ASB-1 | ||||||||||||
| External IDs | OMIM: 605758 MGI: 1929735 HomoloGene: 9390 GeneCards: ASB1 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51665 | 65247 | |||||||||||
| Ensembl | ENSG00000065802 | ENSMUSG00000026311 | |||||||||||
| UniProt | Q9Y576 | Q9WV74 | |||||||||||
| RefSeq (mRNA) | NM_001040445 | NM_001039126 | |||||||||||
| RefSeq (protein) | NP_001035535 | NP_001034215 | |||||||||||
| Location (UCSC) | Chr 2: 239.34 – 239.36 Mb | Chr 1: 91.54 – 91.56 Mb | |||||||||||
| PubMed search | |||||||||||||
Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene.[1]
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.[1]
References
Further reading
- Kile BT, Schulman BA, Alexander WS et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kile BT, Metcalf D, Mifsud S et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
- Kile BT, Viney EM, Willson TA et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
- Hirosawa M, Nagase T, Ishikawa K et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
- Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.