ASAH2B

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B
Identifiers
SymbolsASAH2B ; ASAH2C; ASAH2L; bA449O16.3
External IDsOMIM: 610987 IUPHAR: 2493 GeneCards: ASAH2B Gene
EC number3.5.1.23
Orthologs
SpeciesHumanMouse
Entrez653308n/a
EnsemblENSG00000204147n/a
UniProtP0C7U1n/a
RefSeq (mRNA)NM_001079516n/a
RefSeq (protein)NP_001072984n/a
Location (UCSC)Chr 10:
52.5 – 52.58 Mb		n/a
PubMed searchn/a

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.[1][2]

Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.[1]

References

  1. ↑ 1.0 1.1 Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.
  2. ↑ Deloukas P, Earthrowl ME, Grafham DV et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.

Further reading

  • Brandenberger R, Wei H, Zhang S et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.