ARIH2

Ariadne RBR E3 ubiquitin protein ligase 2

Identifiers

ARIH2 ; ARI2; TRIAD1

External IDs

OMIM: 605615 MGI: 1344361 HomoloGene: 48424 GeneCards: ARIH2 Gene

Gene ontology
Molecular function	• nucleic acid binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity
Cellular component	• nucleus • cytoplasm
Biological process	• protein polyubiquitination • multicellular organismal development • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • developmental cell growth • protein K63-linked ubiquitination • protein K48-linked ubiquitination • hematopoietic stem cell proliferation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000177479

ENSMUSG00000064145

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
48.96 – 49.02 Mb

Chr 9:
108.6 – 108.65 Mb

PubMed search

Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.^[1]^[2]

References

↑ van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557–61. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847. Vancouver style error (help)
↑ "Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics 155 (3): 1231–44. PMC 1461160. PMID 10880484. Vancouver style error (help)
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY et al. (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T et al. (2005). "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells". Blood 106 (13): 4114–23. doi:10.1182/blood-2005-04-1450. PMID 16118314.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T et al. (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood 110 (9): 3128–35. doi:10.1182/blood-2006-11-058602. PMID 17646546.