ARHGAP8
| Rho GTPase activating protein 8 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ARHGAP8 ; BPGAP1; PP610 | ||||||||||||
| External IDs | OMIM: 609405 MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23779 | 73167 | |||||||||||
| Ensembl | ENSG00000241484 | ENSMUSG00000078954 | |||||||||||
| UniProt | P85298 | Q9CXP4 | |||||||||||
| RefSeq (mRNA) | NM_001017526 | NM_001164627 | |||||||||||
| RefSeq (protein) | NP_001017526 | NP_001158099 | |||||||||||
| Location (UCSC) | Chr 22: 45.1 – 45.26 Mb | Chr 15: 84.72 – 84.77 Mb | |||||||||||
| PubMed search | |||||||||||||
Rho GTPase-activating protein 8 is an protein that in humans is encoded by the ARHGAP8 gene.[1][2]
Function
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[2]
References
- ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208.
- ↑ 2.0 2.1 "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8".
Further reading
- Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
- Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8". Gene 303: 55–61. doi:10.1016/S0378-1119(02)01143-5. PMID 12559566.
- Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–45914. doi:10.1074/jbc.M304514200. PMID 12944407.
- Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration". Mol. Biol. Cell 15 (6): 2873–2883. doi:10.1091/mbc.E04-02-0141. PMC 420110. PMID 15064355.
- Johnstone CN, Castellví-Bel S, Chang LM, Bessa X, Nakagawa H, Harada H et al. (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers". Gene 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID 15225876. Vancouver style error (help)
- Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID 15506981.
- Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell. Sci. 118 (Pt 12): 2707–2721. doi:10.1242/jcs.02383. PMID 15944398.