ARFGEF2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3L8N, 3SWV

Identifiers

Symbols

ARFGEF2 ; BIG2; PVNH2; dJ1164I10.1

External IDs

OMIM: 605371 MGI: 2139354 HomoloGene: 111880 GeneCards: ARFGEF2 Gene

Gene ontology
Molecular function	• guanyl-nucleotide exchange factor activity • ARF guanyl-nucleotide exchange factor activity • protein binding • myosin binding • protein kinase A regulatory subunit binding • GABA receptor binding
Cellular component	• Golgi membrane • trans-Golgi network • microtubule organizing center • cytosol • axonemal microtubule • membrane • cytoplasmic membrane-bounded vesicle • cell junction • cytoplasmic vesicle • asymmetric synapse • symmetric synapse • dendritic spine • perinuclear region of cytoplasm • recycling endosome
Biological process	• receptor recycling • exocytosis • Golgi to plasma membrane transport • endosome organization • endomembrane system organization • protein transport • vesicle-mediated transport • regulation of ARF protein signal transduction • positive regulation of tumor necrosis factor production • intracellular signal transduction • positive regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
47.54 – 47.65 Mb

Chr 2:
166.81 – 166.9 Mb

PubMed search

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.^[1]^[2]

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.^[2]

Interactions

ARFGEF2 has been shown to interact with ARFGEF1,^[3] PRKAR1A^[4] and PRKAR2A.^[4]

References

↑ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Jun 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". J Biol Chem 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
↑ 2.0 2.1 "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".
↑ Yamaji, R; Adamik R; Takeda K; Togawa A; Pacheco-Rodriguez G; Ferrans V J; Moss J; Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. ISSN 0027-8424. PMC 15969. PMID 10716990.
↑ 4.0 4.1 Li, Hewang; Adamik Ronald, Pacheco-Rodriguez Gustavo, Moss Joel, Vaughan Martha (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 1627–32. doi:10.1073/pnas.0337678100. ISSN 0027-8424. PMC 149883. PMID 12571360.

Yamaji R, Adamik R, Takeda K et al. (2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
Kamei Y, Takeda Y, Teramoto K et al. (2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.". Genomics 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors.". Meth. Enzymol. 345: 397–404. doi:10.1016/S0076-6879(02)45032-X. PMID 11665623.
Shinotsuka C, Yoshida Y, Kawamoto K et al. (2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation.". J. Biol. Chem. 277 (11): 9468–73. doi:10.1074/jbc.M112427200. PMID 11777925.
Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Shinotsuka C, Waguri S, Wakasugi M et al. (2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.". Biochem. Biophys. Res. Commun. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li H, Adamik R, Pacheco-Rodriguez G et al. (2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.
Sheen VL, Ganesh VS, Topcu M et al. (2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.". Nat. Genet. 36 (1): 69–76. doi:10.1038/ng1276. PMID 14647276.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Xu KF, Shen X, Li H et al. (2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2784–9. doi:10.1073/pnas.0409871102. PMC 549493. PMID 15705715.
Lu J, Tiao G, Folkerth R et al. (2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.". J. Comp. Neurol. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Islam A, Shen X, Hiroi T et al. (2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles.". J. Biol. Chem. 282 (13): 9591–9. doi:10.1074/jbc.M607122200. PMID 17276987.
Kuroda F, Moss J, Vaughan M (2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMC 1805514. PMID 17360629.

ARFGEF2

Interactions

References

Further reading