APC internal ribosome entry site (IRES)
| APC internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_APC | |
| Identifiers | |
| Symbol | IRES_APC |
| Rfam | RF00462 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | 0043022 |
| SO | 0000243 |
The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.[1]
References
- ↑ Heppner, Goss K; Trzepacz C; Tuohy TM; Groden J (2002). "Attenuated APC alleles produce functional protein from internal translation initiation". Proc Natl Acad Sci USA 99 (12): 8161–8166. doi:10.1073/pnas.112072199. PMC 123038. PMID 12034871.