AP1M2

Adaptor-related protein complex 1, mu 2 subunit

Identifiers

AP1M2 ; AP1-mu2; HSMU1B; MU-1B; MU1B; mu2

External IDs

OMIM: 607309 MGI: 1336974 HomoloGene: 55906 GeneCards: AP1M2 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• Golgi membrane • lysosomal membrane • cytosol • clathrin adaptor complex • cytoplasmic vesicle membrane • clathrin-coated vesicle membrane • trans-Golgi network membrane
Biological process	• protein targeting • post-Golgi vesicle-mediated transport • vesicle targeting • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • regulation of defense response to virus by virus • membrane organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
10.68 – 10.7 Mb

Chr 9:
21.3 – 21.31 Mb

PubMed search

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.^[1]^[2]

This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.^[2]

Interactions

AP1M2 has been shown to interact with AP2B1.^[3]

References

↑ Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T, Bonifacino JS (June 1999). "Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells". FEBS Lett 449 (2–3): 215–20. doi:10.1016/S0014-5793(99)00432-9. PMID 10338135.
↑ 2.0 2.1 "Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit".
↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Hirst J, Robinson MS (1998). "Clathrin and adaptors". Biochim. Biophys. Acta 1404 (1–2): 173–93. doi:10.1016/S0167-4889(98)00056-1. PMID 9714795.
Ohno H, Stewart J, Fournier MC et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Seaman MN, Sowerby PJ, Robinson MS (1996). "Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network". J. Biol. Chem. 271 (41): 25446–51. doi:10.1074/jbc.271.41.25446. PMID 8810314.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". Biochem. J. 335 (3): 567–72. PMC 1219817. PMID 9794796.
Berlioz-Torrent C, Shacklett BL, Erdtmann L et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. PMC 103959. PMID 9882340.
Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
Nakatsu F, Kadohira T, Gilbert DJ et al. (2000). "Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2)". Cytogenet. Cell Genet. 87 (1–2): 53–8. doi:10.1159/000015391. PMID 10640811.
Umeda A, Meyerholz A, Ungewickell E (2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation". Eur. J. Cell Biol. 79 (5): 336–42. doi:10.1078/S0171-9335(04)70037-0. PMID 10887964.
Fölsch H, Pypaert M, Schu P, Mellman I (2001). "Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells". J. Cell Biol. 152 (3): 595–606. doi:10.1083/jcb.152.3.595. PMC 2195989. PMID 11157985.
Wyss S, Berlioz-Torrent C, Boge M et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
Ohka S, Ohno H, Tohyama K, Nomoto A (2001). "Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells". Biochem. Biophys. Res. Commun. 287 (4): 941–8. doi:10.1006/bbrc.2001.5660. PMID 11573956.
Korolchuk VI, Banting G (2003). "CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles". Traffic 3 (6): 428–39. doi:10.1034/j.1600-0854.2002.30606.x. PMID 12010461.
Collins BM, McCoy AJ, Kent HM et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell 109 (4): 523–35. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608.
Sugimoto H, Sugahara M, Fölsch H et al. (2003). "Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells". Mol. Biol. Cell 13 (7): 2374–82. doi:10.1091/mbc.E01-10-0096. PMC 117320. PMID 12134076.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

AP1M2 human gene location in the UCSC Genome Browser.
AP1M2 human gene details in the UCSC Genome Browser.

AP1M2

Interactions

References

Further reading

External links