AP1G1
AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.[1][2]
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.[3]
Interactions
AP1G1 has been shown to interact with RABEP1,[4][5] AP1B1,[2][6][7] Synaptophysin,[8] AP1M1,[6][7] NECAP2,[9] AP1S1[2][6][7] and AP1GBP1.[4][10]
References
- ↑ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlen S, Dumanski JP (October 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
- ↑ 2.0 2.1 2.2 Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (October 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
- ↑ "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit".
- ↑ 4.0 4.1 Nogi, Terukazu; Shiba Yoko, Kawasaki Masato, Shiba Tomoo, Matsugaki Naohiro, Igarashi Noriyuki, Suzuki Mamoru, Kato Ryuichi, Takatsu Hiroyuki, Nakayama Kazuhisa, Wakatsuki Soichi (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. (United States) 9 (7): 527–31. doi:10.1038/nsb808. ISSN 1072-8368. PMID 12042876.
- ↑ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5–Rabex-5 complex". EMBO J. (England) 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986.
- ↑ 6.0 6.1 6.2 Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell (UNITED STATES) 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737.
- ↑ 7.0 7.1 7.2 Page, L J; Robinson M S (November 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. (UNITED STATES) 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184.
- ↑ Horikawa, Hiroshi P M; Kneussel Matthias; El Far Oussama; Betz Heinrich (November 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Mol. Cell. Neurosci. (United States) 21 (3): 454–62. doi:10.1006/mcne.2002.1191. ISSN 1044-7431. PMID 12498786.
- ↑ Mattera, Rafael; Ritter Brigitte; Sidhu Sachdev S; McPherson Peter S; Bonifacino Juan S (February 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. (United States) 279 (9): 8018–28. doi:10.1074/jbc.M311873200. ISSN 0021-9258. PMID 14665628.
- ↑ Takatsu, H; Yoshino K; Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. (UNITED STATES) 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. ISSN 0006-291X. PMID 10814529.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Berlioz-Torrent C, Shacklett BL, Erdtmann L et al. (1999). "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins". J. Virol. 73 (2): 1350–61. PMC 103959. PMID 9882340.
- Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "γ-Synergin: An Eh Domain–Containing Protein That Interacts with γ-Adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
- Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
- Hirst J, Lui WW, Bright NA et al. (2000). "A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome". J. Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
- Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- Nakagawa T, Setou M, Seog D et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728.
- Wyss S, Berlioz-Torrent C, Boge M et al. (2001). "The Highly Conserved C-Terminal Dileucine Motif in the Cytosolic Domain of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Is Critical for Its Association with the AP-1 Clathrin Adapter". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
- Crump CM, Xiang Y, Thomas L et al. (2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". EMBO J. 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMC 125242. PMID 11331585.
- Takatsu H, Futatsumori M, Yoshino K et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
- Orzech E, Livshits L, Leyt J et al. (2001). "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". J. Biol. Chem. 276 (33): 31340–8. doi:10.1074/jbc.M101054200. PMID 11418592.
- Doray B, Kornfeld S (2001). "γ Subunit of the AP-1 Adaptor Complex Binds Clathrin: Implications for Cooperative Binding in Coated Vesicle Assembly". Mol. Biol. Cell 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC 55640. PMID 11451993.
- Shiba Y, Takatsu H, Shin HW, Nakayama K (2002). "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain". J. Biochem. 131 (3): 327–36. doi:10.1093/oxfordjournals.jbchem.a003107. PMID 11872161.
- Austin C, Boehm M, Tooze SA (2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry 41 (14): 4669–77. doi:10.1021/bi016064j. PMID 11926829.
- Eiraku M, Hirata Y, Takeshima H et al. (2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". J. Biol. Chem. 277 (28): 25400–7. doi:10.1074/jbc.M110793200. PMID 11950833.
- Nogi T, Shiba Y, Kawasaki M et al. (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876.
- Kalthoff C, Groos S, Kohl R et al. (2003). "Clint: A Novel Clathrin-binding ENTH-Domain Protein at the Golgi". Mol. Biol. Cell 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.
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