ANP32E

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsANP32E ; LANP-L; LANPL
External IDsOMIM: 609611 MGI: 1913721 HomoloGene: 137403 GeneCards: ANP32E Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez8161166471
EnsemblENSG00000143401ENSMUSG00000015749
UniProtQ9BTT0P97822
RefSeq (mRNA)NM_001136478NM_001253757
RefSeq (protein)NP_001129950NP_001240686
Location (UCSC)Chr 1:
150.19 – 150.21 Mb
Chr 3:
95.93 – 95.95 Mb
PubMed search

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.[1][2] The ANP32E gene is located on chromosome 1q22.[1] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.[3] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis[4] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.[5]

See also

References

  1. 1.0 1.1 Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741.
  2. "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".
  3. Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature 505 (7485): 648–53. doi:10.1038/nature12922. PMID 24463511.
  4. Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440.
  5. Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690.

Further reading