ANKRD25

KN motif and ankyrin repeat domains 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4HBD

Identifiers

KANK2 ; ANKRD25; MXRA3; SIP

External IDs

OMIM: 614610 MGI: 2384568 HomoloGene: 9163 GeneCards: KANK2 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • mitochondrion
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • apoptotic process • negative regulation of cell proliferation • negative regulation of intracellular estrogen receptor signaling pathway • negative regulation of programmed cell death • negative regulation of G1/S transition of mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000197256

ENSMUSG00000032194

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
11.27 – 11.31 Mb

Chr 9:
21.77 – 21.8 Mb

PubMed search

KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene.^[1]^[2]^[3]

References

↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
↑ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
↑ "Entrez Gene: ANKRD25 ankyrin repeat domain 25".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wistow G, Bernstein SL, Wyatt MK et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Zhang Y, Zhang H, Liang J et al. (2007). "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.". EMBO J. 26 (11): 2645–57. doi:10.1038/sj.emboj.7601710. PMC 1888672. PMID 17476305.