ANKRD1
Ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the ANKRD1 gene.[1][2]
Function
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.[2]
Interactions
ANKRD1 has been shown to interact with Titin[3] and MYPN.[3][4]
References
- ↑ Chu W, Burns DK, Swerlick RA, Presky DH (June 1995). "Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells". J. Biol. Chem. 270 (17): 10236–45. doi:10.1074/jbc.270.17.10236. PMID 7730328.
- ↑ 2.0 2.1 "Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle)".
- ↑ 3.0 3.1 Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K et al. (November 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. PMID 14583192.
- ↑ Bang ML, Mudry RE, McElhinny AS, Trombitás K, Geach AJ, Yamasaki R et al. (April 2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies". J. Cell Biol. 153 (2): 413–27. doi:10.1083/jcb.153.2.413. PMC 2169455. PMID 11309420. Vancouver style error (help)
Further reading
- Bang ML, Mudry RE, McElhinny AS, Trombitás K, Geach AJ, Yamasaki R et al. (2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies". J. Cell Biol. 153 (2): 413–27. doi:10.1083/jcb.153.2.413. PMC 2169455. PMID 11309420. Vancouver style error (help)
- Zolk O, Frohme M, Maurer A, Kluxen FW, Hentsch B, Zubakov D et al. (2002). "Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure". Biochem. Biophys. Res. Commun. 293 (5): 1377–82. doi:10.1016/S0006-291X(02)00387-X. PMID 12054667.
- de Waard V, van Achterberg TA, Beauchamp NJ, Pannekoek H, de Vries CJ (2003). "Cardiac ankyrin repeat protein (CARP) expression in human and murine atherosclerotic lesions: activin induces CARP in smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 23 (1): 64–8. doi:10.1161/01.ATV.0000042218.13101.50. PMID 12524226.
- Nakamura K, Nakada C, Takeuchi K, Osaki M, Shomori K, Kato S et al. (2003). "Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich region, in atrophic muscles in amyotrophic lateral sclerosis". Pathobiology 70 (4): 197–203. doi:10.1159/000069329. PMID 12679596.
- Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K et al. (2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. PMID 14583192.
- Torrado M, Nespereira B, López E, Centeno A, Castro-Beiras A, Mikhailov AT (2005). "ANKRD1 specifically binds CASQ2 in heart extracts and both proteins are co-enriched in piglet cardiac Purkinje cells". J. Mol. Cell. Cardiol. 38 (2): 353–65. doi:10.1016/j.yjmcc.2004.11.034. PMID 15698842. Vancouver style error (help)
- Park JH, Liu L, Kim IH, Kim JH, You KR, Kim DG (2005). "Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells". Cancer Res. 65 (7): 2804–14. doi:10.1158/0008-5472.CAN-04-2221. PMID 15805281.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Witt SH, Labeit D, Granzier H, Labeit S, Witt CC (2005). "Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling". J. Muscle Res. Cell. Motil. 26 (6-8): 401–8. doi:10.1007/s10974-005-9022-9. PMID 16450059.
- Matsuura K, Uesugi N, Hijiya N, Uchida T, Moriyama M (2007). "Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis". Hum. Pathol. 38 (3): 410–9. doi:10.1016/j.humpath.2006.09.006. PMID 17239933.