AMG-36
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| Systematic (IUPAC) name | |
|---|---|
| (6aR,10aR)-3-(1-hexylcyclopentyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | |
| Clinical data | |
| Identifiers | |
| PubChem | CID 10982174 |
| ChemSpider |
9157375  |
| ChEMBL |
CHEMBL108868 |
| Chemical data | |
| Formula | C27H40O2 |
| 396.604 g/mol | |
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SMILES
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| (what is this?) (verify) | |
AMG-36 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.4nM at CB1 vs 1.9nM at CB2.[1][2]
References
- ↑ Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
- ↑ Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444