ALOXE3

Arachidonate lipoxygenase 3

Identifiers

ALOXE3 ; ARCI3; E-LOX; eLOX-3; eLOX3

External IDs

OMIM: 607206 MGI: 1345140 HomoloGene: 8013 IUPHAR: 1390 GeneCards: ALOXE3 Gene

Gene ontology
Molecular function	• iron ion binding • protein binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • hepoxilin A3 synthase activity
Cellular component	• cytoplasm
Biological process	• sphingolipid metabolic process • sensory perception of pain • arachidonic acid metabolic process • lipoxygenase pathway • peroxisome proliferator activated receptor signaling pathway • linoleic acid metabolic process • fat cell differentiation • ceramide biosynthetic process • hepoxilin biosynthetic process • oxidation-reduction process • establishment of skin barrier
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000179148

ENSMUSG00000020892

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
8 – 8.02 Mb

Chr 11:
69.13 – 69.15 Mb

PubMed search

Epidermis-type lipoxygenase 3 is an enzyme that in humans is encoded by the ALOXE3 gene.^[1]

The leukotrienes constitute a group of arachidonic acid-derived compounds with biologic activities suggesting important roles in inflammation and immediate hypersensitivity. These compounds are catabolized, in part, by lipoxygenases. Epidermis-type lipoxygenases, a distinct subclass within the multigene family of mammalian lipoxygenases, are novel isoenzymes isolated from human and mouse skin including human ALOX15B (MIM 603697), human and mouse ALOX12B (MIM 603741), mouse 8S-LOX, and mouse e-LOX-3.[supplied by OMIM]^[1]

References

↑ 1.0 1.1 "Entrez Gene: ALOXE3 arachidonate lipoxygenase 3".

Further reading

Yu Z, Schneider C, Boeglin WE, Brash AR (2007). "Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.". Lipids 42 (6): 491–7. doi:10.1007/s11745-007-3054-4. PMID 17436029.
Lesueur F, Bouadjar B, Lefèvre C et al. (2007). "Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.". J. Invest. Dermatol. 127 (4): 829–34. doi:10.1038/sj.jid.5700640. PMID 17139268.
Yu Z, Schneider C, Boeglin WE, Brash AR (2007). "Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.". Arch. Biochem. Biophys. 455 (2): 188–96. doi:10.1016/j.abb.2006.09.002. PMC 2636205. PMID 17045234.
Yu Z, Schneider C, Boeglin WE, Brash AR (2005). "Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.". Biochim. Biophys. Acta 1686 (3): 238–47. doi:10.1016/j.bbalip.2004.10.007. PMID 15629692.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jobard F, Lefèvre C, Karaduman A et al. (2002). "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.". Hum. Mol. Genet. 11 (1): 107–13. doi:10.1093/hmg/11.1.107. PMID 11773004.
Krieg P, Marks F, Fürstenberger G (2001). "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.". Genomics 73 (3): 323–30. doi:10.1006/geno.2001.6519. PMID 11350124.