AKAP7

A kinase (PRKA) anchor protein 7
Identifiers
Symbols	AKAP7 ; AKAP15; AKAP18
External IDs	OMIM: 604693 MGI: 1859150 HomoloGene: 49463 GeneCards: AKAP7 Gene
Gene ontology Molecular function • nucleotide binding • catalytic activity • protein binding • protein kinase binding • protein kinase A regulatory subunit binding • protein kinase A binding Cellular component • nucleus • cytosol • plasma membrane • apical plasma membrane • lateral plasma membrane Biological process • action potential • ion transport • protein localization • biological_process • metabolic process • intracellular signal transduction • regulation of membrane repolarization • cellular response to cAMP • positive regulation of potassium ion transmembrane transport • positive regulation of delayed rectifier potassium channel activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9465	432442
Ensembl	ENSG00000118507	ENSMUSG00000039166
UniProt	O43687	O55074
RefSeq (mRNA)	NM_004842	NM_018747
RefSeq (protein)	NP_004833	NP_061217
Location (UCSC)	Chr 6: 131.46 – 131.6 Mb	Chr 10: 25.17 – 25.31 Mb
PubMed search

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.^[1][2]

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.^[2]

References

Further reading