AKAP3
A kinase (PRKA) anchor protein 3 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | AKAP3 ; AKAP 110; AKAP110; CT82; FSP95; HEL159; PRKA3; SOB1 | ||||||||||||
External IDs | OMIM: 604689 MGI: 1341149 HomoloGene: 4688 GeneCards: AKAP3 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 10566 | 11642 | |||||||||||
Ensembl | ENSG00000111254 | ENSMUSG00000030344 | |||||||||||
UniProt | O75969 | O88987 | |||||||||||
RefSeq (mRNA) | NM_001278309 | NM_009650 | |||||||||||
RefSeq (protein) | NP_001265238 | NP_033780 | |||||||||||
Location (UCSC) | Chr 12: 4.72 – 4.76 Mb | Chr 6: 126.85 – 126.87 Mb | |||||||||||
PubMed search | |||||||||||||
A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.[1][2][3]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.[3]
Interactions
AKAP3 has been shown to interact with:
References
- ↑ Lefevre A, Duquenne C, Rousseau-Merck MF, Rogier E, Finaz C (May 1999). "Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition". Biochemical and Biophysical Research Communications 259 (1): 60–6. doi:10.1006/bbrc.1999.0728. PMID 10334916.
- ↑ 2.0 2.1 Vijayaraghavan S, Liberty GA, Mohan J, Winfrey VP, Olson GE, Carr DW (May 1999). "Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein". Molecular Endocrinology 13 (5): 705–17. doi:10.1210/mend.13.5.0278. PMID 10319321.
- ↑ 3.0 3.1 "Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3".
- ↑ Brown PR, Miki K, Harper DB, Eddy EM (Jun 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum". Biology of Reproduction 68 (6): 2241–8. doi:10.1095/biolreprod.102.013466. PMID 12606363.
- ↑ Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N et al. (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology 11 (21): 1686–90. doi:10.1016/S0960-9822(01)00530-9. PMID 11696326.
- ↑ Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S (May 2001). "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA". The Journal of Biological Chemistry 276 (20): 17332–8. doi:10.1074/jbc.M011252200. PMID 11278869.
Further reading
- Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Progress in Hormone Research 52: 409–29; discussion 429–30. PMID 9238861.
- Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annual Review of Pharmacology and Toxicology 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- Mandal A, Naaby-Hansen S, Wolkowicz MJ, Klotz K, Shetty J, Retief JD et al. (Nov 1999). "FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa". Biology of Reproduction 61 (5): 1184–97. doi:10.1095/biolreprod61.5.1184. PMID 10529264.
- Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S (May 2001). "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA". The Journal of Biological Chemistry 276 (20): 17332–8. doi:10.1074/jbc.M011252200. PMID 11278869.
- Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N et al. (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology 11 (21): 1686–90. doi:10.1016/S0960-9822(01)00530-9. PMID 11696326.
- Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P et al. (Mar 2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". The Journal of Biological Chemistry 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
- Brown PR, Miki K, Harper DB, Eddy EM (Jun 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum". Biology of Reproduction 68 (6): 2241–8. doi:10.1095/biolreprod.102.013466. PMID 12606363.
- Hasegawa K, Ono T, Matsushita H, Shimono M, Noguchi Y, Mizutani Y et al. (Jan 2004). "A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis". International Journal of Cancer. Journal International Du Cancer 108 (1): 86–90. doi:10.1002/ijc.11565. PMID 14618620.
- Lea IA, Widgren EE, O'Rand MG (Jul 2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reproductive Biology and Endocrinology 2: 57. doi:10.1186/1477-7827-2-57. PMC 484205. PMID 15257753.
- Sharma S, Qian F, Keitz B, Driscoll D, Scanlan MJ, Skipper J et al. (Oct 2005). "A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer". Gynecologic Oncology 99 (1): 183–8. doi:10.1016/j.ygyno.2005.06.006. PMID 16005946.
- Lefièvre L, Chen Y, Conner SJ, Scott JL, Publicover SJ, Ford WC et al. (Sep 2007). "Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?". Proteomics 7 (17): 3066–84. doi:10.1002/pmic.200700254. PMC 2777308. PMID 17683036. Vancouver style error (help)