AKAP10
| A kinase (PRKA) anchor protein 10 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | AKAP10 ; AKAP-10; D-AKAP-2; D-AKAP2; PRKA10 | ||||||||||||
| External IDs | OMIM: 604694 MGI: 1890218 HomoloGene: 32452 GeneCards: AKAP10 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11216 | 56697 | |||||||||||
| Ensembl | ENSG00000108599 | ENSMUSG00000047804 | |||||||||||
| UniProt | O43572 | O88845 | |||||||||||
| RefSeq (mRNA) | NM_007202 | NM_019921 | |||||||||||
| RefSeq (protein) | NP_009133 | NP_064305 | |||||||||||
| Location (UCSC) | Chr 17: 19.81 – 19.88 Mb | Chr 11: 61.87 – 61.93 Mb | |||||||||||
| PubMed search | |||||||||||||
A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.[1][2]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.[2]
Interactions
AKAP10 has been shown to interact with PDZK1[3] and PRKAR1A.[1][4]
References
- ↑ 1.0 1.1 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. doi:10.1073/pnas.94.21.11184. PMC 23409. PMID 9326583.
- ↑ 2.0 2.1 "Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10".
- ↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA et al. (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29; discussion 429–30. PMID 9238861.
- Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". Hum. Genet. 93 (1): 35–41. doi:10.1007/BF00218910. PMID 7505766.
- Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M et al. (2001). "Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3220–5. doi:10.1073/pnas.051633398. PMC 30634. PMID 11248059.
- Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V (2002). "Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS)". J. Mol. Biol. 321 (4): 703–14. doi:10.1016/S0022-2836(02)00419-9. PMID 12206784.
- Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM et al. (2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4066–71. doi:10.1073/pnas.2628028100. PMC 153049. PMID 12646697.
- Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA et al. (2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
- Burns-Hamuro LL, Barraclough DM, Taylor SS (2004). "Identification and functional analysis of dual-specific A kinase-anchoring protein-2". Meth. Enzymol. Methods in Enzymology 390: 354–74. doi:10.1016/S0076-6879(04)90022-5. ISBN 978-0-12-182795-3. PMID 15488188.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG et al. (2007). "Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation". Proc. Natl. Acad. Sci. U.S.A. 104 (20): 8461–6. doi:10.1073/pnas.0610393104. PMC 1866184. PMID 17485678.