AGTRAP

Angiotensin II receptor-associated protein

Identifiers

AGTRAP ; ATRAP

External IDs

OMIM: 608729 MGI: 1339977 HomoloGene: 7621 GeneCards: AGTRAP Gene

Gene ontology
Molecular function	• angiotensin type II receptor activity • protein binding
Cellular component	• Golgi membrane • endoplasmic reticulum membrane • plasma membrane • cell cortex • integral component of membrane • cytoplasmic vesicle membrane
Biological process	• response to hypoxia • regulation of blood pressure • angiotensin-activated signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000177674

ENSMUSG00000029007

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
11.8 – 11.81 Mb

Chr 4:
148.08 – 148.09 Mb

PubMed search

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.^[1]^[2]

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.^[2]

Interactions

AGTRAP has been shown to interact with GNB2L1.^[1]

References

↑ 1.0 1.1 Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
↑ 2.0 2.1 "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

Further reading

Daviet L, Lehtonen JY, Tamura K et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. doi:10.1074/jbc.274.24.17058. PMID 10358057.
Cui T, Nakagami H, Iwai M et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
Wistow G, Bernstein SL, Wyatt MK et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell 14 (12): 5038–50. doi:10.1091/mbc.E03-06-0383. PMC 284805. PMID 12960423.
Guo DF, Chenier I, Tardif V et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
Guo DF, Tardif V, Ghelima K et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200. PMID 14985364.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. doi:10.1074/jbc.M500296200. PMID 15668245.
Tanaka Y, Tamura K, Koide Y et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.