AEBP2

AE binding protein 2
Identifiers
SymbolAEBP2
External IDsHomoloGene: 40690 GeneCards: AEBP2 Gene
Orthologs
SpeciesHumanMouse
Entrez12153611569
EnsemblENSG00000139154ENSMUSG00000030232
UniProtQ6ZN18Q9Z248
RefSeq (mRNA)NM_001114176NM_001005605
RefSeq (protein)NP_001107648NP_001005605
Location (UCSC)Chr 12:
19.56 – 19.87 Mb		Chr 6:
140.62 – 140.68 Mb
PubMed search

Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).[1]

Function

AEBP2 is a DNA-binding transcriptional repressor. It may interact with and stimulate the activity of the PRC2 complex.[2]

AEBP2 may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.[3]

Clinical significance

Diseases associated with AEBP2 include Waardenburg's syndrome, and Hirschsprung's disease.[3]

References

  1. ↑ Kim H, Kang K, Ekram MB, Roh TY, Kim J (2011). "Aebp2 as an epigenetic regulator for neural crest cells". PLoS ONE 6 (9): e25174. doi:10.1371/journal.pone.0025174. PMID 21949878.
  2. ↑ Cao R, Zhang Y (July 2004). "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Mol. Cell 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
  3. ↑ 3.0 3.1 Kim H, Kang K, Kim J (2009). "AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2". Nucleic Acids Res. 37 (9): 2940–50. doi:10.1093/nar/gkp149. PMID 19293275.