ADAMTSL4
| ADAMTS-like 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ADAMTSL4 ; ADAMTSL-4; ECTOL2; TSRC1 | ||||||||||||
| External IDs | OMIM: 610113 MGI: 2389008 HomoloGene: 23141 GeneCards: ADAMTSL4 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54507 | 229595 | |||||||||||
| Ensembl | ENSG00000143382 | ENSMUSG00000015850 | |||||||||||
| UniProt | Q6UY14 | Q80T21 | |||||||||||
| RefSeq (mRNA) | NM_001288607 | NM_144899 | |||||||||||
| RefSeq (protein) | NP_001275536 | NP_659148 | |||||||||||
| Location (UCSC) | Chr 1: 150.55 – 150.56 Mb | Chr 3: 95.68 – 95.69 Mb | |||||||||||
| PubMed search | |||||||||||||
ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.[1][2]
Function
This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
References
- ↑ Buchner DA, Meisler MH (Mar 2003). "TSRC1, a widely expressed gene containing seven thrombospondin type I repeats". Gene 307: 23–30. doi:10.1016/S0378-1119(03)00423-2. PMID 12706885.
- ↑ 2.0 2.1 "Entrez Gene: ADAMTSL4 ADAMTS-like 4".
Further reading
- Adams JC, Tucker RP (Jun 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Developmental Dynamics 218 (2): 280–299. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W et al. (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–3496. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L et al. (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America 101 (44): 15724–15729. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
- Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Liu J, Guo Q, Chen B, Yu Y, Lu H, Li YY (Jan 2006). "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90". FEBS Letters 580 (1): 245–250. doi:10.1016/j.febslet.2005.12.005. PMID 16364318.