ADAMTS8
| ADAM metallopeptidase with thrombospondin type 1 motif, 8 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ADAMTS8 ; ADAM-TS8; METH2 | ||||||||||||
| External IDs | OMIM: 605175 MGI: 1353468 HomoloGene: 5108 IUPHAR: 1681 GeneCards: ADAMTS8 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11095 | 30806 | |||||||||||
| Ensembl | ENSG00000134917 | ENSMUSG00000031994 | |||||||||||
| UniProt | Q9UP79 | P57110 | |||||||||||
| RefSeq (mRNA) | NM_007037 | NM_013906 | |||||||||||
| RefSeq (protein) | NP_008968 | NP_038934 | |||||||||||
| Location (UCSC) | Chr 11: 130.27 – 130.3 Mb | Chr 9: 30.94 – 30.96 Mb | |||||||||||
| PubMed search | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.[1][2]
Function
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.[2]
Clinical significance
A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.[2]
References
- ↑ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
- ↑ 2.0 2.1 2.2 "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8".
Further reading
- Wågsäter D, Björk H, Zhu C et al. (2008). "ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.". Atherosclerosis 196 (2): 514–22. doi:10.1016/j.atherosclerosis.2007.05.018. PMID 17606262.
- Dunn JR, Reed JE, du Plessis DG et al. (2006). "Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours.". Br. J. Cancer 94 (8): 1186–93. doi:10.1038/sj.bjc.6603006. PMC 2361255. PMID 16570050.
- Porter S, Span PN, Sweep FC et al. (2006). "ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.". Int. J. Cancer 118 (5): 1241–7. doi:10.1002/ijc.21476. PMID 16152618.
- Dunn JR, Panutsopulos D, Shaw MW et al. (2004). "METH-2 silencing and promoter hypermethylation in NSCLC.". Br. J. Cancer 91 (6): 1149–54. doi:10.1038/sj.bjc.6602107. PMC 2747718. PMID 15328519.
- Collins-Racie LA, Flannery CR, Zeng W et al. (2005). "ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.". Matrix Biol. 23 (4): 219–30. doi:10.1016/j.matbio.2004.05.004. PMID 15296936.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Georgiadis KE, Hirohata S, Seldin MF, Apte SS (2000). "ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11.". Genomics 62 (2): 312–5. doi:10.1006/geno.1999.6014. PMID 10610729.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| |||||||||||||||||||||