ADAM18
| ADAM metallopeptidase domain 18 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ADAM18 ; ADAM27; tMDCIII | ||||||||||||
| External IDs | MGI: 105986 HomoloGene: 74941 IUPHAR: 1663 GeneCards: ADAM18 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8749 | 13524 | |||||||||||
| Ensembl | ENSG00000168619 | ENSMUSG00000031552 | |||||||||||
| UniProt | Q9Y3Q7 | Q9R157 | |||||||||||
| RefSeq (mRNA) | NM_001190956 | NM_010084 | |||||||||||
| RefSeq (protein) | NP_001177885 | NP_034214 | |||||||||||
| Location (UCSC) | Chr 8: 39.44 – 39.59 Mb | Chr 8: 24.6 – 24.67 Mb | |||||||||||
| PubMed search | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[1][2]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[2]
References
- ↑ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
- ↑ 2.0 2.1 "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".
Further reading
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization.". Gene 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
- Frayne J, Jury JA, Barker HL et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract.". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
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