ACYP2
| Acylphosphatase 2, muscle type | |||||||||||||
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 PDB rendering based on 1aps. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ACYP2 ; ACYM; ACYP | ||||||||||||
| External IDs | OMIM: 102595 MGI: 1922822 HomoloGene: 41776 GeneCards: ACYP2 Gene | ||||||||||||
| EC number | 3.6.1.7 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 98 | 75572 | |||||||||||
| Ensembl | ENSG00000170634 | ENSMUSG00000060923 | |||||||||||
| UniProt | P14621 | P56375 | |||||||||||
| RefSeq (mRNA) | NM_138448 | NM_029344 | |||||||||||
| RefSeq (protein) | NP_612457 | NP_083620 | |||||||||||
| Location (UCSC) | Chr 2: 54.2 – 54.53 Mb | Chr 11: 30.51 – 30.65 Mb | |||||||||||
| PubMed search | |||||||||||||
Acylphosphatase-2 is an enzyme that in humans is encoded by the ACYP2 gene.[1][2]
Function
Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation.[2]
References
- ↑ Modesti A, Raugei G, Taddei N, Marzocchini R, Vecchi M, Camici G et al. (Dec 1993). "Chemical synthesis and expression of a gene coding for human muscle acylphosphatase". Biochimica Et Biophysica Acta 1216 (3): 369–74. doi:10.1016/0167-4781(93)90003-v. PMID 8268218.
- ↑ 2.0 2.1 "Entrez Gene: ACYP2 acylphosphatase 2, muscle type".
Further reading
- Parrini C, Taddei N, Ramazzotti M, Degl'Innocenti D, Ramponi G, Dobson CM et al. (Aug 2005). "Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation". Structure 13 (8): 1143–1151. doi:10.1016/j.str.2005.04.022. PMID 16084386.
- Calamai M, Canale C, Relini A, Stefani M, Chiti F, Dobson CM (Feb 2005). "Reversal of protein aggregation provides evidence for multiple aggregated States". Journal of Molecular Biology 346 (2): 603–616. doi:10.1016/j.jmb.2004.11.067. PMID 15670608.
- Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G et al. (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase". The Journal of Biological Chemistry 278 (1): 194–199. doi:10.1074/jbc.M206918200. PMID 12409302.
- Chiti F, Taddei N, Baroni F, Capanni C, Stefani M, Ramponi G et al. (Feb 2002). "Kinetic partitioning of protein folding and aggregation". Nature Structural Biology 9 (2): 137–143. doi:10.1038/nsb752. PMID 11799398.
- Chiti F, Taddei N, White PM, Bucciantini M, Magherini F, Stefani M et al. (Nov 1999). "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding". Nature Structural Biology 6 (11): 1005–1009. doi:10.1038/14890. PMID 10542090.
- Fiaschi T, Marzocchini R, Raugei G, Veggi D, Chiarugi P, Ramponi G (Nov 1997). "The 5'-untranslated region of the human muscle acylphosphatase mRNA has an inhibitory effect on protein expression". FEBS Letters 417 (1): 130–134. doi:10.1016/S0014-5793(97)01270-2. PMID 9395090.
- Chiarugi P, Degl'Innocenti D, Raugei G, Fiaschi T, Ramponi G (Feb 1997). "Differential migration of acylphosphatase isoenzymes from cytoplasm to nucleus during apoptotic cell death". Biochemical and Biophysical Research Communications 231 (3): 717–721. doi:10.1006/bbrc.1997.6176. PMID 9070879.
- Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters 367 (2): 145–148. doi:10.1016/0014-5793(95)00553-L. PMID 7796909.
- Chiarugi P, Raugei G, Marzocchini R, Fiaschi T, Ciccarelli C, Berti A et al. (Oct 1995). "Differential modulation of expression of the two acylphosphatase isoenzymes by thyroid hormone". The Biochemical Journal. 311 ( Pt 2) (2): 567–73. PMC 1136037. PMID 7487897.
- Manao G, Camici G, Modesti A, Liguri G, Berti A, Stefani M et al. (Dec 1984). "Human skeletal muscle acylphosphatase: the primary structure". Molecular Biology & Medicine 2 (6): 369–78. PMID 6100723.
- Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A et al. (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry 25 (24): 8089–8094. doi:10.1021/bi00372a044. PMID 3026468.
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