ACYP1
| Acylphosphatase 1, erythrocyte (common) type | |||||||||||||
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 Rendering based on PDB 2K7J. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ACYP1 ; ACYPE | ||||||||||||
| External IDs | OMIM: 600875 MGI: 1913454 HomoloGene: 11932 GeneCards: ACYP1 Gene | ||||||||||||
| EC number | 3.6.1.7 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 97 | 66204 | |||||||||||
| Ensembl | ENSG00000119640 | ENSMUSG00000008822 | |||||||||||
| UniProt | P07311 | P56376 | |||||||||||
| RefSeq (mRNA) | NM_001107 | NM_025421 | |||||||||||
| RefSeq (protein) | NP_001098 | NP_079697 | |||||||||||
| Location (UCSC) | Chr 14: 75.52 – 75.54 Mb | Chr 12: 85.27 – 85.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.[1][2][3]
Function
Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.[3]
References
- ↑ Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters 367 (2): 145–8. doi:10.1016/0014-5793(95)00553-L. PMID 7796909.
- ↑ Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M et al. (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics 81 (3-4): 235–6. doi:10.1159/000015037. PMID 9730610.
- ↑ 3.0 3.1 "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".
Further reading
- Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry 266 (17): 10867–71. PMID 1645713.
- Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry 12 (4): 450–9. PMID 2169259.
- Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A et al. (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry 25 (24): 8089–94. doi:10.1021/bi00372a044. PMID 3026468.
- Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G et al. (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase". The Journal of Biological Chemistry 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302.
- Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life 56 (1): 29–33. doi:10.1080/15216540310001654349. PMID 14992377.