ACTG1

Actin, gamma 1

PDB rendering based on 1atn.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1atn, 1c0f, 1c0g, 1d4x, 1dej, 1eqy, 1esv, 1h1v, 1hlu, 1ijj, 1j6z, 1kxp, 1lcu, 1lot, 1m8q, 1ma9, 1mdu, 1mvw, 1nlv, 1nm1, 1nmd, 1nwk, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g, 1p8z, 1qz5, 1qz6, 1rdw, 1rfq, 1rgi, 1s22, 1sqk, 1t44, 1wua, 1y64, 1yxq, 2a3z, 2a40, 2a41, 2a42, 2a5x, 2asm, 2aso, 2asp, 2btf, 2d1k, 2ff3, 2ff6, 2fxu, 2gwj, 2gwk, 2hf3, 2hf4, 2hmp, 2oan, 2q1n, 2q31, 2q36

Identifiers

Symbols

ACTG1 ; ACT; ACTG; BRWS2; DFNA20; DFNA26; HEL-176

External IDs

OMIM: 102560 MGI: 87906 HomoloGene: 74402 GeneCards: ACTG1 Gene

Gene ontology
Molecular function	• structural constituent of cytoskeleton • protein binding • ATP binding • identical protein binding
Cellular component	• extracellular space • nucleus • cytosol • cytoskeleton • membrane • myofibril • filamentous actin • extracellular vesicular exosome • blood microparticle
Biological process	• retina homeostasis • cellular component movement • axon guidance • cell junction assembly • adherens junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • innate immune response • sarcomere organization • cell-cell junction organization • membrane organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
79.48 – 79.49 Mb

Chr 11:
120.35 – 120.35 Mb

PubMed search

Actin, gamma 1, also known as ACTG1, is a gene.

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells.^[1]

Interactions

ACTG1 has been shown to interact with TMSB4X^[2]^[3] and CAP1.^[4]

References

↑ "Entrez Gene: ACTG1 actin, gamma 1".
↑ Hertzog, Maud; van Heijenoort Carine, Didry Dominique, Gaudier Martin, Coutant Jérôme, Gigant Benoît, Didelot Gérard, Préat Thomas, Knossow Marcel, Guittet Eric, Carlier Marie-France (May 2004). "The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly". Cell (United States) 117 (5): 611–23. doi:10.1016/S0092-8674(04)00403-9. ISSN 0092-8674. PMID 15163409.
↑ Van Troys, M; Dewitte D; Goethals M; Carlier M F; Vandekerckhove J; Ampe C (Jan 1996). "The actin binding site of thymosin beta 4 mapped by mutational analysis". EMBO J. (ENGLAND) 15 (2): 201–10. ISSN 0261-4189. PMC 449934. PMID 8617195.
↑ Hubberstey, A; Yu G; Loewith R; Lakusta C; Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". J. Cell. Biochem. (UNITED STATES) 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. ISSN 0730-2312. PMID 8761950.

Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha) 42 (5): 227–30. doi:10.1007/BF02818986. PMID 8997639.
Rodríguez Del Castillo A, Vitale ML, Trifaró JM (1992). "Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation". J. Cell Biol. 119 (4): 797–810. doi:10.1083/jcb.119.4.797. PMC 2289683. PMID 1331119.
Adams LD, Tomasselli AG, Robbins P et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes". AIDS Res. Hum. Retroviruses 8 (2): 291–5. doi:10.1089/aid.1992.8.291. PMID 1540415.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Tomasselli AG, Hui JO, Adams L et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279.
Shoeman RL, Kesselmier C, Mothes E et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199–203. doi:10.1016/0014-5793(91)80116-K. PMID 1991513.
Erba HP, Eddy R, Shows T et al. (1988). "Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes". Mol. Cell. Biol. 8 (4): 1775–89. PMC 363338. PMID 2837653.
Vandekerckhove J, Schering B, Bärmann M, Aktories K (1988). "Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177". J. Biol. Chem. 263 (2): 696–700. PMID 3335520.
Chou CC, Davis RC, Fuller ML et al. (1987). "Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related". Proceedings of the National Academy of Sciences of the United States of America 84 (9): 2575–9. doi:10.1073/pnas.84.9.2575. PMC 304700. PMID 3472224.
Hesterberg LK, Weber K (1986). "Isolation of a domain of villin retaining calcium-dependent interaction with G-actin, but devoid of F-actin fragmenting activity". Eur. J. Biochem. 154 (1): 135–40. doi:10.1111/j.1432-1033.1986.tb09368.x. PMID 3510866.
Erba HP, Gunning P, Kedes L (1986). "Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes". Nucleic Acids Res. 14 (13): 5275–94. doi:10.1093/nar/14.13.5275. PMC 311540. PMID 3737401.
Fuchs E, Kim KH, Hanukoglu I, Tanese N (1984). "The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells". Curr. Probl. Dermatol. 11: 27–44. PMID 6686106.
Gunning P, Ponte P, Okayama H et al. (1983). "Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed". Mol. Cell. Biol. 3 (5): 787–95. PMC 368601. PMID 6865942.
Bretscher A, Weber K (1980). "Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner". Cell 20 (3): 839–47. doi:10.1016/0092-8674(80)90330-X. PMID 6893424.
Pedrotti B, Colombo R, Islam K (1995). "Microtubule associated protein MAP1A is an actin-binding and crosslinking protein". Cell Motil. Cytoskeleton 29 (2): 110–6. doi:10.1002/cm.970290203. PMID 7820861.
Pope B, Maciver S, Weeds A (1995). "Localization of the calcium-sensitive actin monomer binding site in gelsolin to segment 4 and identification of calcium binding sites". Biochemistry 34 (5): 1583–8. doi:10.1021/bi00005a014. PMID 7849017.
Jesaitis AJ, Erickson RW, Klotz KN et al. (1993). "Functional molecular complexes of human N-formyl chemoattractant receptors and actin". J. Immunol. 151 (10): 5653–65. PMID 8228254.
Hawkins M, Pope B, Maciver SK, Weeds AG (1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry 32 (38): 9985–93. doi:10.1021/bi00089a014. PMID 8399167.
Yu FX, Lin SC, Morrison-Bogorad M et al. (1993). "Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins". J. Biol. Chem. 268 (1): 502–9. PMID 8416954.
Jalaguier S, Mornet D, Mesnier D et al. (1996). "Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation". FEBS Lett. 384 (2): 112–6. doi:10.1016/0014-5793(96)00295-5. PMID 8612804.

PDB gallery

1atn: Atomic structure of the actin:DNASE I complex

1c0f: CRYSTAL STRUCTURE OF DICTYOSTELIUM CAATP-ACTIN IN COMPLEX WITH GELSOLIN SEGMENT 1

1c0g: CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H)

1d4x: Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution.

1dej: CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1

1eqy: COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1

1esv: COMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 1

1h1v: GELSOLIN G4-G6/ACTIN COMPLEX

1hlu: STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE

1ijj: THE X-RAY CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RABBIT SKELETAL MUSCLE ACTIN AND LATRUNCULIN A AT 2.85 A RESOLUTION

1j6z: UNCOMPLEXED ACTIN

1kxp: CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN

1lcu: Polylysine Induces an Antiparallel Actin Dimer that Nucleates Filament Assembly: Crystal Structure at 3.5 A Resolution

1lot: CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN

1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle

1ma9: Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin

1mdu: Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1)

1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1nlv: Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1

1nm1: Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A Resolution

1nmd: Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP

1nwk: CRYSTAL STRUCTURE OF MONOMERIC ACTIN IN THE ATP STATE

1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1p8z: Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156

1qz5: Structure of rabbit actin in complex with kabiramide C

1qz6: Structure of rabbit actin in complex with jaspisamide A

1rdw: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer

1rfq: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer

1rgi: Crystal structure of gelsolin domains G1-G3 bound to actin

1s22: Absolute Stereochemistry of Ulapualide A

1sqk: CRYSTAL STRUCTURE OF CIBOULOT IN COMPLEX WITH SKELETAL ACTIN

1t44: Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation

1wua: The structure of Aplyronine A-actin complex

1y64: Bni1p Formin Homology 2 Domain complexed with ATP-actin

1yxq: Crystal structure of actin in complex with swinholide A

2a3z: Ternary complex of the WH2 domain of WASP with Actin-DNAse I

2a40: Ternary complex of the WH2 domain of WAVE with Actin-DNAse I

2a41: Ternary complex of the WH2 Domain of WIP with Actin-DNAse I

2a42: Actin-DNAse I Complex

2a5x: Crystal Structure of a Cross-linked Actin Dimer

2asm: Structure of Rabbit Actin In Complex With Reidispongiolide A

2aso: Structure of Rabbit Actin In Complex With Sphinxolide B

2asp: Structure of Rabbit Actin In Complex With Reidispongiolide C

2btf: THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN

2d1k: Ternary complex of the WH2 domain of mim with actin-dnase I

2ff3: Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin

2ff6: Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin

2fxu: X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.

2gwj: SpvB ADP-ribosylated actin: hexagonal crystal form

2gwk: SpvB ADP-ribosylated actin: orthorhombic crystal form

2hf3: Crystal structure of monomeric Actin in the ADP bound state

2hf4: Crystal structure of Monomeric Actin in its ATP-bound state

2hmp: Uncomplexed actin cleaved with protease ECP32

2oan: Structure of oxidized beta-actin

2q1n: Actin Dimer Cross-linked Between Residues 41 and 374

2q31: Actin Dimer Cross-linked Between Residues 41 and 374 and proteolytically cleaved by subtilisin between residues 47 and 48.

2q36: Actin Dimer Cross-linked between Residues 191 and 374 and complexed with Kabiramide C

Proteins of the cytoskeleton

Human

Microfilaments
(ABPs)

Myofilament

Actins	A1 A2 B C1 G1 G2

Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1

Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Wiskott-Aldrich syndrome protein
Fibrillin
Filamin
- FLNA
- FLNB
- FLNC
Espin
TRIOBP

IFs

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 7 8 9

Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86

Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80

Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Lamin A
B

Microtubules/
MAPs

Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3

Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3

Other	Tau protein Dynactin DCTN1 Tubulins TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3

Catenins

Membrane

Dystrophin
- Dystroglycan
Utrophin
Ankyrin
- ANK1
- ANK2
- ANK3
Spectrin
- SPTA1
- SPTAN1
- SPTB
- SPTBN1
- SPTBN2
- SPTBN4
- SPTBN5

Other

Nonhuman

See also: cytoskeletal defects

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins

ACTG1

Interactions

See also

References

Further reading