ABTB1
| Ankyrin repeat and BTB (POZ) domain containing 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ABTB1 ; BPOZ; BTB3; BTBD21; EF1ABP | ||||||||||||
| External IDs | OMIM: 608308 MGI: 1933148 HomoloGene: 32731 GeneCards: ABTB1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 80325 | 80283 | |||||||||||
| Ensembl | ENSG00000114626 | ENSMUSG00000030083 | |||||||||||
| UniProt | Q969K4 | Q99LJ2 | |||||||||||
| RefSeq (mRNA) | NM_032548 | NM_030251 | |||||||||||
| RefSeq (protein) | NP_115937 | NP_084527 | |||||||||||
| Location (UCSC) | Chr 3: 127.39 – 127.4 Mb | Chr 6: 88.84 – 88.84 Mb | |||||||||||
| PubMed search | |||||||||||||
Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.[1][2][3]
Function
This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.[3]
References
- ↑ Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain". Biochem Biophys Res Commun 273 (3): 991–6. doi:10.1006/bbrc.2000.3053. PMID 10891360.
- ↑ Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene 20 (33): 4457–65. doi:10.1038/sj.onc.1204608. PMID 11494141.
- ↑ 3.0 3.1 "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1".
Further reading
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Wan D, Gong Y, Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.