ABCG4
| ATP-binding cassette, sub-family G (WHITE), member 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ABCG4 ; WHITE2 | ||||||||||||
| External IDs | OMIM: 607784 MGI: 1890594 HomoloGene: 75179 IUPHAR: 793 GeneCards: ABCG4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64137 | 192663 | |||||||||||
| Ensembl | ENSG00000172350 | ENSMUSG00000032131 | |||||||||||
| UniProt | Q9H172 | Q91WA9 | |||||||||||
| RefSeq (mRNA) | NM_001142505 | NM_138955 | |||||||||||
| RefSeq (protein) | NP_001135977 | NP_620405 | |||||||||||
| Location (UCSC) | Chr 11: 119.02 – 119.03 Mb | Chr 9: 44.27 – 44.29 Mb | |||||||||||
| PubMed search | |||||||||||||
ATP-binding cassette sub-family G member 4 is a protein that in humans is encoded by the ABCG4 gene.[1][2]
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.[2]
See also
References
- ↑ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397.
- ↑ 2.0 2.1 "Entrez Gene: ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4".
Further reading
- Engel T, Lorkowski S, Lueken A et al. (2001). "The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages.". Biochem. Biophys. Res. Commun. 288 (2): 483–8. doi:10.1006/bbrc.2001.5756. PMID 11606068.
- Annilo T, Tammur J, Hutchinson A et al. (2002). "Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4.". Cytogenet. Cell Genet. 94 (3-4): 196–201. doi:10.1159/000048816. PMID 11856881.
- Yoshikawa M, Yabuuchi H, Kuroiwa A et al. (2002). "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4.". Gene 293 (1-2): 67–75. doi:10.1016/S0378-1119(02)00719-9. PMID 12137944.
- Oldfield S, Lowry C, Ruddick J, Lightman S (2002). "ABCG4: a novel human white family ABC-transporter expressed in the brain and eye.". Biochim. Biophys. Acta 1591 (1-3): 175–9. doi:10.1016/S0167-4889(02)00269-0. PMID 12183068.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cserepes J, Szentpétery Z, Seres L et al. (2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.". Biochem. Biophys. Res. Commun. 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Engel T, Bode G, Lueken A et al. (2006). "Expression and functional characterization of ABCG1 splice variant ABCG1(666).". FEBS Lett. 580 (18): 4551–9. doi:10.1016/j.febslet.2006.07.006. PMID 16870176.
- Vaughan AM, Oram JF (2007). "ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.". J. Lipid Res. 47 (11): 2433–43. doi:10.1194/jlr.M600218-JLR200. PMID 16902247.
External links
- ABCG4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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